Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005298239> ?p ?o ?g. }
- W2005298239 endingPage "368" @default.
- W2005298239 startingPage "360" @default.
- W2005298239 abstract "Abstract DNA interaction with quaternary diammonium dications, R(CH 3 ) 2 N + (CH 2 ) n N + (CH 3 ) 2 R, having various intercharge distances, lengths, and branching, and the chemical nature of the hydrophobic substituents were investigated by fluorescent microscopy and circular dichroism (CD) spectroscopy to reveal their structural specificity for binding to DNA. The conformational behavior of DNA was found to be highly sensitive to the structure of the dications with separated charges. The distance between two ammonium groups greatly influences the compaction activity of the dications. To explain this situation, we proposed a model that demonstrates that the charge density of the dication and the geometric fit between DNA phosphates and the ammonium groups in the dications play an important role in providing efficient DNA collapse. Elongation of the alkyl substituents (R) in the diammonium salts from ethyl to hexyl did not generate any significant alterations in the compaction activities, whereas the branching of substituents caused a drastic decrease in their compaction ability. Based on the results of CD spectroscopy, it was found that the ability of the dications to provoke a DNA transition from the B‐form to A‐form was also specific: it depended on their intercharge distances and was independent of the length of alkyl substituents." @default.
- W2005298239 created "2016-06-24" @default.
- W2005298239 creator A5001597356 @default.
- W2005298239 creator A5010168885 @default.
- W2005298239 creator A5052831648 @default.
- W2005298239 creator A5065822716 @default.
- W2005298239 creator A5076369380 @default.
- W2005298239 date "2004-02-26" @default.
- W2005298239 modified "2023-10-18" @default.
- W2005298239 title "DNA Compaction by Divalent Cations: Structural Specificity Revealed by the Potentiality of Designed Quaternary Diammonium Salts" @default.
- W2005298239 cites W1499595669 @default.
- W2005298239 cites W1533307088 @default.
- W2005298239 cites W1544991224 @default.
- W2005298239 cites W1561888630 @default.
- W2005298239 cites W1970429992 @default.
- W2005298239 cites W1971605196 @default.
- W2005298239 cites W1972450401 @default.
- W2005298239 cites W1973756121 @default.
- W2005298239 cites W1976785536 @default.
- W2005298239 cites W1978732060 @default.
- W2005298239 cites W1980706221 @default.
- W2005298239 cites W1982117833 @default.
- W2005298239 cites W1982809791 @default.
- W2005298239 cites W1988416664 @default.
- W2005298239 cites W1991303534 @default.
- W2005298239 cites W1992799817 @default.
- W2005298239 cites W1999242162 @default.
- W2005298239 cites W2000802897 @default.
- W2005298239 cites W2004388607 @default.
- W2005298239 cites W2004518911 @default.
- W2005298239 cites W2008911030 @default.
- W2005298239 cites W2013769305 @default.
- W2005298239 cites W2018390158 @default.
- W2005298239 cites W2028328757 @default.
- W2005298239 cites W2040304965 @default.
- W2005298239 cites W2052948676 @default.
- W2005298239 cites W2053427405 @default.
- W2005298239 cites W2056144602 @default.
- W2005298239 cites W2065057935 @default.
- W2005298239 cites W2067229943 @default.
- W2005298239 cites W2067930125 @default.
- W2005298239 cites W2069000639 @default.
- W2005298239 cites W2070247422 @default.
- W2005298239 cites W2070287692 @default.
- W2005298239 cites W2071683671 @default.
- W2005298239 cites W2074414331 @default.
- W2005298239 cites W2075759218 @default.
- W2005298239 cites W2092447252 @default.
- W2005298239 cites W2094840617 @default.
- W2005298239 cites W2102834112 @default.
- W2005298239 cites W2141778672 @default.
- W2005298239 cites W2150303730 @default.
- W2005298239 cites W2160774940 @default.
- W2005298239 cites W2169722716 @default.
- W2005298239 cites W2179868684 @default.
- W2005298239 cites W4233309778 @default.
- W2005298239 doi "https://doi.org/10.1002/cbic.200300797" @default.
- W2005298239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14997528" @default.
- W2005298239 hasPublicationYear "2004" @default.
- W2005298239 type Work @default.
- W2005298239 sameAs 2005298239 @default.
- W2005298239 citedByCount "59" @default.
- W2005298239 countsByYear W20052982392013 @default.
- W2005298239 countsByYear W20052982392014 @default.
- W2005298239 countsByYear W20052982392015 @default.
- W2005298239 countsByYear W20052982392016 @default.
- W2005298239 countsByYear W20052982392017 @default.
- W2005298239 countsByYear W20052982392019 @default.
- W2005298239 countsByYear W20052982392020 @default.
- W2005298239 countsByYear W20052982392021 @default.
- W2005298239 countsByYear W20052982392022 @default.
- W2005298239 countsByYear W20052982392023 @default.
- W2005298239 crossrefType "journal-article" @default.
- W2005298239 hasAuthorship W2005298239A5001597356 @default.
- W2005298239 hasAuthorship W2005298239A5010168885 @default.
- W2005298239 hasAuthorship W2005298239A5052831648 @default.
- W2005298239 hasAuthorship W2005298239A5065822716 @default.
- W2005298239 hasAuthorship W2005298239A5076369380 @default.
- W2005298239 hasConcept C133571119 @default.
- W2005298239 hasConcept C178790620 @default.
- W2005298239 hasConcept C185592680 @default.
- W2005298239 hasConcept C206175624 @default.
- W2005298239 hasConcept C2779870022 @default.
- W2005298239 hasConcept C2780263894 @default.
- W2005298239 hasConcept C552990157 @default.
- W2005298239 hasConcept C55493867 @default.
- W2005298239 hasConcept C71240020 @default.
- W2005298239 hasConcept C74884574 @default.
- W2005298239 hasConcept C8010536 @default.
- W2005298239 hasConceptScore W2005298239C133571119 @default.
- W2005298239 hasConceptScore W2005298239C178790620 @default.
- W2005298239 hasConceptScore W2005298239C185592680 @default.
- W2005298239 hasConceptScore W2005298239C206175624 @default.
- W2005298239 hasConceptScore W2005298239C2779870022 @default.
- W2005298239 hasConceptScore W2005298239C2780263894 @default.
- W2005298239 hasConceptScore W2005298239C552990157 @default.
- W2005298239 hasConceptScore W2005298239C55493867 @default.
- W2005298239 hasConceptScore W2005298239C71240020 @default.