Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005298766> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2005298766 endingPage "5833" @default.
- W2005298766 startingPage "5825" @default.
- W2005298766 abstract "Hydroxyaminolactams have been used as constrained surrogates of the Ser-Leu dipeptide in the synthesis of analogues of the cycloheptapeptide stylostatin 1 (2). The rate of cyclization through formation of the Ile-Pro amide bond allowed us to prove that the valerolactams used induced a turn in the linear precursor. Ring closure at the Pro-Phe amide bond was much quicker and provided access to larger amounts of the target structures, with high purity. The conformation of ψ-stylostatin 4 was compared to that of native stylostatin 1 using NMR analysis. The ability of three ψ-stylostatins and the native stylostatin 1 to inhibit growth of cancer cell lines was tested. None of the compounds showed activity below 1 μM. A possible relationship between the decrease in activity and the presence of the piperidone Ser-Leu surrogate is considered." @default.
- W2005298766 created "2016-06-24" @default.
- W2005298766 creator A5002147300 @default.
- W2005298766 creator A5026992536 @default.
- W2005298766 creator A5037246000 @default.
- W2005298766 creator A5037738920 @default.
- W2005298766 creator A5051374780 @default.
- W2005298766 creator A5086768524 @default.
- W2005298766 creator A5089218483 @default.
- W2005298766 date "2003-11-21" @default.
- W2005298766 modified "2023-09-25" @default.
- W2005298766 title "Constrained Derivatives of Stylostatin 1. 1. Synthesis and Biological Evaluation as Potential Anticancer Agents" @default.
- W2005298766 cites W1983972173 @default.
- W2005298766 cites W2022408308 @default.
- W2005298766 cites W2053878174 @default.
- W2005298766 cites W2059322172 @default.
- W2005298766 cites W2082385881 @default.
- W2005298766 cites W2089696378 @default.
- W2005298766 cites W2109689528 @default.
- W2005298766 cites W2163267664 @default.
- W2005298766 doi "https://doi.org/10.1021/jm030943h" @default.
- W2005298766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14667235" @default.
- W2005298766 hasPublicationYear "2003" @default.
- W2005298766 type Work @default.
- W2005298766 sameAs 2005298766 @default.
- W2005298766 citedByCount "8" @default.
- W2005298766 countsByYear W20052987662012 @default.
- W2005298766 countsByYear W20052987662016 @default.
- W2005298766 countsByYear W20052987662019 @default.
- W2005298766 countsByYear W20052987662020 @default.
- W2005298766 crossrefType "journal-article" @default.
- W2005298766 hasAuthorship W2005298766A5002147300 @default.
- W2005298766 hasAuthorship W2005298766A5026992536 @default.
- W2005298766 hasAuthorship W2005298766A5037246000 @default.
- W2005298766 hasAuthorship W2005298766A5037738920 @default.
- W2005298766 hasAuthorship W2005298766A5051374780 @default.
- W2005298766 hasAuthorship W2005298766A5086768524 @default.
- W2005298766 hasAuthorship W2005298766A5089218483 @default.
- W2005298766 hasConcept C114373084 @default.
- W2005298766 hasConcept C116073593 @default.
- W2005298766 hasConcept C178790620 @default.
- W2005298766 hasConcept C185592680 @default.
- W2005298766 hasConcept C202751555 @default.
- W2005298766 hasConcept C21951064 @default.
- W2005298766 hasConcept C2778439535 @default.
- W2005298766 hasConcept C2779138802 @default.
- W2005298766 hasConcept C2779281246 @default.
- W2005298766 hasConcept C2780378348 @default.
- W2005298766 hasConcept C31684184 @default.
- W2005298766 hasConcept C55493867 @default.
- W2005298766 hasConcept C71240020 @default.
- W2005298766 hasConceptScore W2005298766C114373084 @default.
- W2005298766 hasConceptScore W2005298766C116073593 @default.
- W2005298766 hasConceptScore W2005298766C178790620 @default.
- W2005298766 hasConceptScore W2005298766C185592680 @default.
- W2005298766 hasConceptScore W2005298766C202751555 @default.
- W2005298766 hasConceptScore W2005298766C21951064 @default.
- W2005298766 hasConceptScore W2005298766C2778439535 @default.
- W2005298766 hasConceptScore W2005298766C2779138802 @default.
- W2005298766 hasConceptScore W2005298766C2779281246 @default.
- W2005298766 hasConceptScore W2005298766C2780378348 @default.
- W2005298766 hasConceptScore W2005298766C31684184 @default.
- W2005298766 hasConceptScore W2005298766C55493867 @default.
- W2005298766 hasConceptScore W2005298766C71240020 @default.
- W2005298766 hasIssue "26" @default.
- W2005298766 hasLocation W20052987661 @default.
- W2005298766 hasLocation W20052987662 @default.
- W2005298766 hasOpenAccess W2005298766 @default.
- W2005298766 hasPrimaryLocation W20052987661 @default.
- W2005298766 hasRelatedWork W1967309651 @default.
- W2005298766 hasRelatedWork W2005298766 @default.
- W2005298766 hasRelatedWork W2031118126 @default.
- W2005298766 hasRelatedWork W2071329968 @default.
- W2005298766 hasRelatedWork W2092845367 @default.
- W2005298766 hasRelatedWork W2326193183 @default.
- W2005298766 hasRelatedWork W2951112430 @default.
- W2005298766 hasRelatedWork W2997309562 @default.
- W2005298766 hasRelatedWork W4244161199 @default.
- W2005298766 hasRelatedWork W4247315058 @default.
- W2005298766 hasVolume "46" @default.
- W2005298766 isParatext "false" @default.
- W2005298766 isRetracted "false" @default.
- W2005298766 magId "2005298766" @default.
- W2005298766 workType "article" @default.