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• W2005299085 abstract "LUZP is a leucine zipper-containing protein predominantly expressed in the brain. The functional significance of LUZP remains unknown. To explore the role of LUZP in brain development, a knockout mouse strain with a lacZ knock-in (Luzp-KO/lacZ-KI) has been established. LacZ reporter expression driven by the endogenous Luzp promoter was detected in the neuroepithelium and the cardiac tissue. Luzp−/− mice exhibited perinatal death, presumably due to the accompanied complex cardiovascular defects. Luzp−/− embryos displayed a cranial neural tube closure defect (NTD), with exposed brain tissues. Ectopic expression of Sonic-hedgehog, which is a protein known to be involved in neural tube closure, and elevated apoptosis were observed in the dorsal lateral neuroepithelium of the NTD Luzp−/− hindbrain. These findings assign a novel function of LUZP in the embryonic development of brain." @default.
• W2005299085 created "2016-06-24" @default.
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• W2005299085 date "2008-11-01" @default.
• W2005299085 modified "2023-10-15" @default.
• W2005299085 title "LUZP deficiency affects neural tube closure during brain development" @default.
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• W2005299085 doi "https://doi.org/10.1016/j.bbrc.2008.08.170" @default.
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