FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005302362> ?p ?o ?g. }

• W2005302362 endingPage "e0119205" @default.
• W2005302362 startingPage "e0119205" @default.
• W2005302362 abstract "Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear. To explore whether alpha-synuclein oligomerization was associated with the cleavage of alpha-synuclein by calpain, we made a rat brain slice model of manganism and pretreated slices with calpain inhibitor II, a cell-permeable peptide that restricts the activity of calpain. After slices were treated with 400 μM Mn for 24 h, there were significant increases in the percentage of apoptotic cells, lactate dehydrogenase release, intracellular [Ca2+]i, calpain activity, and the mRNA and protein expression of calpain 1 and alpha-synuclein. Moreover, the number of C- and N-terminal fragments of alpha-synuclein and the amount of alpha-synuclein oligomerization also increased. These results also showed that calpain inhibitor II pretreatment could reduce Mn-induced nerve cell injury and alpha-synuclein oligomerization. Additionally, there was a significant decrease in the number of C- and N-terminal fragments of alpha-synuclein in calpain inhibitor II-pretreated slices. These findings revealed that Mn induced the cleavage of alpha-synuclein protein via overactivation of calpain and subsequent alpha-synuclein oligomerization in cultured slices. Moreover, the cleavage of alpha-synuclein by calpain 1 is an important signaling event in Mn-induced alpha-synuclein oligomerization." @default.
• W2005302362 created "2016-06-24" @default.
• W2005302362 creator A5003754140 @default.
• W2005302362 creator A5014213683 @default.
• W2005302362 creator A5056417543 @default.
• W2005302362 creator A5071037763 @default.
• W2005302362 creator A5074532635 @default.
• W2005302362 creator A5080258524 @default.
• W2005302362 date "2015-03-10" @default.
• W2005302362 modified "2023-09-26" @default.
• W2005302362 title "Inhibition of Calpain Prevents Manganese-Induced Cell Injury and Alpha-Synuclein Oligomerization in Organotypic Brain Slice Cultures" @default.
• W2005302362 cites W1480183851 @default.
• W2005302362 cites W1548659173 @default.
• W2005302362 cites W1590614500 @default.
• W2005302362 cites W1807475000 @default.
• W2005302362 cites W1943532636 @default.
• W2005302362 cites W1971054388 @default.
• W2005302362 cites W1971389338 @default.
• W2005302362 cites W1979173605 @default.
• W2005302362 cites W1984894634 @default.
• W2005302362 cites W2008686677 @default.
• W2005302362 cites W2009132341 @default.
• W2005302362 cites W2010589225 @default.
• W2005302362 cites W2013542960 @default.
• W2005302362 cites W2015068772 @default.
• W2005302362 cites W2024256106 @default.
• W2005302362 cites W2024919859 @default.
• W2005302362 cites W2030242756 @default.
• W2005302362 cites W2031624140 @default.
• W2005302362 cites W2041037209 @default.
• W2005302362 cites W2041174538 @default.
• W2005302362 cites W2077169013 @default.
• W2005302362 cites W2079054696 @default.
• W2005302362 cites W2080381408 @default.
• W2005302362 cites W2081246142 @default.
• W2005302362 cites W2093922785 @default.
• W2005302362 cites W2094271851 @default.
• W2005302362 cites W2094333303 @default.
• W2005302362 cites W2115316180 @default.
• W2005302362 cites W2117474289 @default.
• W2005302362 cites W2145583587 @default.
• W2005302362 cites W2146924026 @default.
• W2005302362 cites W2153078408 @default.
• W2005302362 cites W2315070794 @default.
• W2005302362 doi "https://doi.org/10.1371/journal.pone.0119205" @default.
• W2005302362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4355489" @default.
• W2005302362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25756858" @default.
• W2005302362 hasPublicationYear "2015" @default.
• W2005302362 type Work @default.
• W2005302362 sameAs 2005302362 @default.
• W2005302362 citedByCount "16" @default.
• W2005302362 countsByYear W20053023622016 @default.
• W2005302362 countsByYear W20053023622017 @default.
• W2005302362 countsByYear W20053023622018 @default.
• W2005302362 countsByYear W20053023622019 @default.
• W2005302362 countsByYear W20053023622020 @default.
• W2005302362 countsByYear W20053023622021 @default.
• W2005302362 crossrefType "journal-article" @default.
• W2005302362 hasAuthorship W2005302362A5003754140 @default.
• W2005302362 hasAuthorship W2005302362A5014213683 @default.
• W2005302362 hasAuthorship W2005302362A5056417543 @default.
• W2005302362 hasAuthorship W2005302362A5071037763 @default.
• W2005302362 hasAuthorship W2005302362A5074532635 @default.
• W2005302362 hasAuthorship W2005302362A5080258524 @default.
• W2005302362 hasBestOaLocation W20053023621 @default.
• W2005302362 hasConcept C126322002 @default.
• W2005302362 hasConcept C153911025 @default.
• W2005302362 hasConcept C159110408 @default.
• W2005302362 hasConcept C181199279 @default.
• W2005302362 hasConcept C185592680 @default.
• W2005302362 hasConcept C2775944032 @default.
• W2005302362 hasConcept C2779134260 @default.
• W2005302362 hasConcept C2779734285 @default.
• W2005302362 hasConcept C2781449126 @default.
• W2005302362 hasConcept C49453240 @default.
• W2005302362 hasConcept C55493867 @default.
• W2005302362 hasConcept C56928146 @default.
• W2005302362 hasConcept C64943373 @default.
• W2005302362 hasConcept C71924100 @default.
• W2005302362 hasConcept C79879829 @default.
• W2005302362 hasConcept C86803240 @default.
• W2005302362 hasConcept C95444343 @default.
• W2005302362 hasConcept C98539663 @default.
• W2005302362 hasConceptScore W2005302362C126322002 @default.
• W2005302362 hasConceptScore W2005302362C153911025 @default.
• W2005302362 hasConceptScore W2005302362C159110408 @default.
• W2005302362 hasConceptScore W2005302362C181199279 @default.
• W2005302362 hasConceptScore W2005302362C185592680 @default.
• W2005302362 hasConceptScore W2005302362C2775944032 @default.
• W2005302362 hasConceptScore W2005302362C2779134260 @default.
• W2005302362 hasConceptScore W2005302362C2779734285 @default.
• W2005302362 hasConceptScore W2005302362C2781449126 @default.
• W2005302362 hasConceptScore W2005302362C49453240 @default.
• W2005302362 hasConceptScore W2005302362C55493867 @default.
• W2005302362 hasConceptScore W2005302362C56928146 @default.
• W2005302362 hasConceptScore W2005302362C64943373 @default.
• W2005302362 hasConceptScore W2005302362C71924100 @default.
• W2005302362 hasConceptScore W2005302362C79879829 @default.

• next