Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005304365> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2005304365 endingPage "40" @default.
- W2005304365 startingPage "31" @default.
- W2005304365 abstract "The present study has examined the role of diltiazem as a protective agent in a canine model of norepinephrine cardiotoxicity. Effects of diltiazem, 20 μg/kg/min × 5 min pretreatment followed by 10 μg/kg/min × 90 min, or saline infusion were examined at baseline and 1 h after infusion of norepinephrine, 4 μg/kg/min for 90 min, in closed-chest anesthetized dogs. Left ventricular function was assessed by equilibrium radionuclide angiogram and two-dimensional echocardiogram. In 7 saline experiments, hypotension and increased heart rate were observed at 1 h post infusion. In the diltiazem-treated group (n = 7), mean arterial pressure and heart rate were unchanged. In the saline group, left ventricular ejection fraction fell from 0.50 ± 0.04 to 0.28 ± 0.04. Left ventricular ejection fraction was unchanged in the diltiazem-treated group: 0.52 ± 0.03 to 0.55 ± 0.07. Left ventricular end-diastolic volume was increased at 1 h post infusion in saline controls but not in the diltiazem-treated group. Measurement of fractional shortening from two-dimensional echocardiograms also indicated left ventricular dysfunction in the saline but not diltiazem-treated groups. Left ventricular end-systolic wall stress following norepinephrine infusion was significantly increased in the saline but not diltiazem-treated groups: 122.7 ± 18.7 vs 67.6 ± 19.7 g/cm2, respectively. In dogs receiving saline without norepinephrine infusion, no significant changes occurred over the course of the experiment. Histologic examination showed mild contraction band necrosis in saline controls but not in sham saline dogs. Diltiazem showed intermediate histologic evidence of injury, which was not further quantified. This study suggests that effects of norepinephrine on left ventricular function in the canine model of norepinephrine cardiotoxicity may be largely due to increased wall stress following a prolonged increase in afterload. Diltiazem pretreatment afforded significant protection of left ventricular function." @default.
- W2005304365 created "2016-06-24" @default.
- W2005304365 creator A5019683977 @default.
- W2005304365 creator A5046371346 @default.
- W2005304365 creator A5054015412 @default.
- W2005304365 creator A5055388887 @default.
- W2005304365 creator A5058568922 @default.
- W2005304365 creator A5066660760 @default.
- W2005304365 creator A5088427447 @default.
- W2005304365 date "1992-07-01" @default.
- W2005304365 modified "2023-09-27" @default.
- W2005304365 title "Effect of diltiazem on norepinephrine-induced acute left ventricular dysfunction" @default.
- W2005304365 cites W2005214956 @default.
- W2005304365 cites W2021568293 @default.
- W2005304365 cites W2028137315 @default.
- W2005304365 cites W2045671518 @default.
- W2005304365 cites W2056522083 @default.
- W2005304365 cites W2084537293 @default.
- W2005304365 cites W2087272299 @default.
- W2005304365 cites W2092713296 @default.
- W2005304365 cites W2104475665 @default.
- W2005304365 cites W2140509811 @default.
- W2005304365 cites W2156982022 @default.
- W2005304365 cites W2312872944 @default.
- W2005304365 cites W2313299250 @default.
- W2005304365 cites W4234467251 @default.
- W2005304365 doi "https://doi.org/10.1016/0167-5273(92)90105-c" @default.
- W2005304365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1428250" @default.
- W2005304365 hasPublicationYear "1992" @default.
- W2005304365 type Work @default.
- W2005304365 sameAs 2005304365 @default.
- W2005304365 citedByCount "5" @default.
- W2005304365 countsByYear W20053043652016 @default.
- W2005304365 countsByYear W20053043652022 @default.
- W2005304365 crossrefType "journal-article" @default.
- W2005304365 hasAuthorship W2005304365A5019683977 @default.
- W2005304365 hasAuthorship W2005304365A5046371346 @default.
- W2005304365 hasAuthorship W2005304365A5054015412 @default.
- W2005304365 hasAuthorship W2005304365A5055388887 @default.
- W2005304365 hasAuthorship W2005304365A5058568922 @default.
- W2005304365 hasAuthorship W2005304365A5066660760 @default.
- W2005304365 hasAuthorship W2005304365A5088427447 @default.
- W2005304365 hasConcept C126322002 @default.
- W2005304365 hasConcept C164705383 @default.
- W2005304365 hasConcept C2776741139 @default.
- W2005304365 hasConcept C2777397205 @default.
- W2005304365 hasConcept C2777953023 @default.
- W2005304365 hasConcept C2778198053 @default.
- W2005304365 hasConcept C2778514916 @default.
- W2005304365 hasConcept C42219234 @default.
- W2005304365 hasConcept C513476851 @default.
- W2005304365 hasConcept C519063684 @default.
- W2005304365 hasConcept C71924100 @default.
- W2005304365 hasConcept C78085059 @default.
- W2005304365 hasConcept C84393581 @default.
- W2005304365 hasConceptScore W2005304365C126322002 @default.
- W2005304365 hasConceptScore W2005304365C164705383 @default.
- W2005304365 hasConceptScore W2005304365C2776741139 @default.
- W2005304365 hasConceptScore W2005304365C2777397205 @default.
- W2005304365 hasConceptScore W2005304365C2777953023 @default.
- W2005304365 hasConceptScore W2005304365C2778198053 @default.
- W2005304365 hasConceptScore W2005304365C2778514916 @default.
- W2005304365 hasConceptScore W2005304365C42219234 @default.
- W2005304365 hasConceptScore W2005304365C513476851 @default.
- W2005304365 hasConceptScore W2005304365C519063684 @default.
- W2005304365 hasConceptScore W2005304365C71924100 @default.
- W2005304365 hasConceptScore W2005304365C78085059 @default.
- W2005304365 hasConceptScore W2005304365C84393581 @default.
- W2005304365 hasIssue "1" @default.
- W2005304365 hasLocation W20053043651 @default.
- W2005304365 hasLocation W20053043652 @default.
- W2005304365 hasOpenAccess W2005304365 @default.
- W2005304365 hasPrimaryLocation W20053043651 @default.
- W2005304365 hasRelatedWork W2031395571 @default.
- W2005304365 hasRelatedWork W2038661164 @default.
- W2005304365 hasRelatedWork W2055279203 @default.
- W2005304365 hasRelatedWork W2156982048 @default.
- W2005304365 hasRelatedWork W2195513968 @default.
- W2005304365 hasRelatedWork W2285354716 @default.
- W2005304365 hasRelatedWork W2361221782 @default.
- W2005304365 hasRelatedWork W2383375557 @default.
- W2005304365 hasRelatedWork W2392801217 @default.
- W2005304365 hasRelatedWork W2443463695 @default.
- W2005304365 hasVolume "36" @default.
- W2005304365 isParatext "false" @default.
- W2005304365 isRetracted "false" @default.
- W2005304365 magId "2005304365" @default.
- W2005304365 workType "article" @default.