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- W2005306152 abstract "The use of ACTH and cortisone in surgery has certain positive indications whereas further investigation is required in other conditions. Patients with frank pituitary-adrenocortical failure requiring operation or those with acute or chronic deficiency may be carried through an emergency by adequate therapy. Although wound healing and granulation tissue production are delayed in animals, results in man vary and probably quite large doses of ACTH or cortisone are necessary to cause delay of granulation tissue formation in a high percentage of surgical patients. Although marked delay of wound healing in some surgical patients may be undesirable, in others it is most useful. For example, a delay of granulation tissue formation to minimize formation of adhesions about severed tendons, tendon grafts and following operations on the hand may be a most valuable therapeutic adjunct to operation. Similar studies should be undertaken on a most important problem, that of abdominal adhesions. Consideration of the physiologic actions of ACTH and cortisone suggested that they might be useful in the treatment of severe thermal burns. Clinical results, however, have been disappointing in a considerable number of instances. In view of the high mortality in extensive burns it would seem advisable to continue animal experimentation and carefully supervised studies on selected burn patients. Treatment of hypertrophic scars and keloids and attempts to prolong the life of homologous grafts of skin have not been encouraging. It appears that the role of ACTH and cortisone in surgical conditions is considerably broader than it was a year ago and its use in surgery may be extended still further." @default.
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- W2005306152 title "Use of ACTH and cortisone in surgery" @default.
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- W2005306152 doi "https://doi.org/10.1016/0002-9610(52)90272-9" @default.
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