FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005307250> ?p ?o ?g. }

• W2005307250 endingPage "969" @default.
• W2005307250 startingPage "964" @default.
• W2005307250 abstract "Previous studies have shown that a high level of dietary lipid (corn oil) exacerbates UV-carcinogenic expression in hairless mice. Furthermore, it was demonstrated that this effect occurs at the postinitiation, or promotion, stage of UV-carcinogenesis-a stage believed to be modulated immunologically. Thus, we sought to examine the influence of dietary lipid on specific immune parameters at various times within a UV-carcinogenic protocol, with the purpose of detecting potential relationships to UV carcinogenesis. Hairless mice were fed either a high- (12%, wt/wt, corn oil) or low-fat (0.75%, wt/wt, corn oil) diet for 2 weeks prior to start of the UV or experimental protocols. Animals were sensitized to dinitrochlorobenzene (DNCB) hapten and delayed-type hypersensitivity (DTH) was assessed. Delayed-type hypersensitivity was significantly suppressed (P= 0.01) in the high-fat group, even before UV irradiation. Although both groups exhibited UV-induced suppression of this response, the high-fat group was totally suppressed after 3 weeks of UV, whereas the low-fat group exhibited reactivity through week 8. The splenic T-lymphocyte (Thy 1.2+) population had declined by about 50% at the time of UV termination (11 weeks). Dietary lipid exerted no apparent influence upon this T-cell population. However, after 6 weeks of UV, I-J+ cells (a marker shown to be acquired adaptively by suppressor T lymphocytes) began to increase. By week 15 (4 weeks post-UV) I-J+ cells had increased by about 65% in the high-fat group, twice the % increase that occurred in the low-fat group. When UV-induced tumors were transplanted to recipient animals receiving various periods (0, 6, 11 weeks) of UV irradiation, no significant differences in median tumor rejection times between the two dietary groups occurred at 0 or 6 weeks. After 11 weeks of UV, the low-fat group exhibited a tumor rejection time that was comparable to that of nonirradiated animals, i.e. 21 days. However, median tumor rejection time for the high-fat group was greater than 63 days, significantly (P= 0.01) longer than that of the low-fat group. Thus, suppression of tumor rejection by high fat occurred at a time when high fat had been shown to exacerbate carcinogenic expression and when I-J+ cells had markedly increased. These data demonstrate that level of dietary lipid modulates immunoresponsiveness in UV-irradiated animals and is compatible with the thesis that immune suppression may account for the exacerbation of carcinogenic expression elicited by high dietary fat." @default.
• W2005307250 created "2016-06-24" @default.
• W2005307250 creator A5019845231 @default.
• W2005307250 creator A5036718607 @default.
• W2005307250 creator A5039526208 @default.
• W2005307250 creator A5057072881 @default.
• W2005307250 creator A5074032445 @default.
• W2005307250 date "2008-01-02" @default.
• W2005307250 modified "2023-10-17" @default.
• W2005307250 title "DIETARY FAT MODULATES IMMUNORESPONSIVENESS IN UV-IRRADIATED MICE" @default.
• W2005307250 cites W1499716799 @default.
• W2005307250 cites W1502355832 @default.
• W2005307250 cites W1556695612 @default.
• W2005307250 cites W1605072294 @default.
• W2005307250 cites W1608273437 @default.
• W2005307250 cites W1789059667 @default.
• W2005307250 cites W1974971041 @default.
• W2005307250 cites W2005777751 @default.
• W2005307250 cites W2020133847 @default.
• W2005307250 cites W2035701106 @default.
• W2005307250 cites W2038735650 @default.
• W2005307250 cites W2043116422 @default.
• W2005307250 cites W2099257808 @default.
• W2005307250 cites W2101218142 @default.
• W2005307250 cites W2106472472 @default.
• W2005307250 cites W2121134545 @default.
• W2005307250 cites W2157565292 @default.
• W2005307250 cites W2232077463 @default.
• W2005307250 cites W2322868828 @default.
• W2005307250 doi "https://doi.org/10.1111/j.1751-1097.1995.tb02394.x" @default.
• W2005307250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8570742" @default.
• W2005307250 hasPublicationYear "2008" @default.
• W2005307250 type Work @default.
• W2005307250 sameAs 2005307250 @default.
• W2005307250 citedByCount "33" @default.
• W2005307250 countsByYear W20053072502012 @default.
• W2005307250 countsByYear W20053072502014 @default.
• W2005307250 countsByYear W20053072502015 @default.
• W2005307250 countsByYear W20053072502016 @default.
• W2005307250 countsByYear W20053072502020 @default.
• W2005307250 crossrefType "journal-article" @default.
• W2005307250 hasAuthorship W2005307250A5019845231 @default.
• W2005307250 hasAuthorship W2005307250A5036718607 @default.
• W2005307250 hasAuthorship W2005307250A5039526208 @default.
• W2005307250 hasAuthorship W2005307250A5057072881 @default.
• W2005307250 hasAuthorship W2005307250A5074032445 @default.
• W2005307250 hasConcept C114246631 @default.
• W2005307250 hasConcept C121608353 @default.
• W2005307250 hasConcept C126322002 @default.
• W2005307250 hasConcept C134018914 @default.
• W2005307250 hasConcept C185592680 @default.
• W2005307250 hasConcept C203014093 @default.
• W2005307250 hasConcept C2778206080 @default.
• W2005307250 hasConcept C2779156968 @default.
• W2005307250 hasConcept C2908647359 @default.
• W2005307250 hasConcept C31903555 @default.
• W2005307250 hasConcept C55493867 @default.
• W2005307250 hasConcept C555283112 @default.
• W2005307250 hasConcept C71924100 @default.
• W2005307250 hasConcept C86803240 @default.
• W2005307250 hasConcept C8891405 @default.
• W2005307250 hasConcept C99454951 @default.
• W2005307250 hasConceptScore W2005307250C114246631 @default.
• W2005307250 hasConceptScore W2005307250C121608353 @default.
• W2005307250 hasConceptScore W2005307250C126322002 @default.
• W2005307250 hasConceptScore W2005307250C134018914 @default.
• W2005307250 hasConceptScore W2005307250C185592680 @default.
• W2005307250 hasConceptScore W2005307250C203014093 @default.
• W2005307250 hasConceptScore W2005307250C2778206080 @default.
• W2005307250 hasConceptScore W2005307250C2779156968 @default.
• W2005307250 hasConceptScore W2005307250C2908647359 @default.
• W2005307250 hasConceptScore W2005307250C31903555 @default.
• W2005307250 hasConceptScore W2005307250C55493867 @default.
• W2005307250 hasConceptScore W2005307250C555283112 @default.
• W2005307250 hasConceptScore W2005307250C71924100 @default.
• W2005307250 hasConceptScore W2005307250C86803240 @default.
• W2005307250 hasConceptScore W2005307250C8891405 @default.
• W2005307250 hasConceptScore W2005307250C99454951 @default.
• W2005307250 hasIssue "6" @default.
• W2005307250 hasLocation W20053072501 @default.
• W2005307250 hasLocation W20053072502 @default.
• W2005307250 hasOpenAccess W2005307250 @default.
• W2005307250 hasPrimaryLocation W20053072501 @default.
• W2005307250 hasRelatedWork W1964010228 @default.
• W2005307250 hasRelatedWork W1996695304 @default.
• W2005307250 hasRelatedWork W2021365476 @default.
• W2005307250 hasRelatedWork W2029251984 @default.
• W2005307250 hasRelatedWork W2035635507 @default.
• W2005307250 hasRelatedWork W2049835156 @default.
• W2005307250 hasRelatedWork W2080290402 @default.
• W2005307250 hasRelatedWork W2126820512 @default.
• W2005307250 hasRelatedWork W2148253648 @default.
• W2005307250 hasRelatedWork W2467318560 @default.
• W2005307250 hasVolume "62" @default.
• W2005307250 isParatext "false" @default.
• W2005307250 isRetracted "false" @default.
• W2005307250 magId "2005307250" @default.
• W2005307250 workType "article" @default.