FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005309151> ?p ?o ?g. }

• W2005309151 endingPage "970" @default.
• W2005309151 startingPage "955" @default.
• W2005309151 abstract "Using CD and NMR, we determined the structure of an RNA oligomer, r(GGAGGUUUUGGAGG) (R14), comprising two GGAGG segments joined by a UUUU segment. A modified quadruplex structure was observed for r(GGAGGUUUUGGAGG) in solution even in the absence of K(+). An unusually stable dimeric RNA quadruplex architecture formed from two strands of r(GGAGGUUUUGGAGG) at low K(+) concentration is reported here. In each strand of r(GGAGGUUUUGGAGG), two sets of successive turns in the GGAGG segments and turns at both ends of the UUUU loops drive four G-G steps to align in a parallel manner, a core with two stacked G-tetrads being formed. Two adenine bases bind to two edges of one G:G:G:G tetrad through the sheared G:A mismatch augmenting the tetrad into a G:G(:A):G:G(:A) hexad. Thus, one molecule of r(GGAGGUUUUGGAGG) folds into a modified quadruplex comprising a G:G:G:G tetrad, a UUUU double-chain reversal loop and a G:G(:A):G:G(:A) hexad. Two such molecules further associate by stacking through the dimeric hexad-hexad interface with a rotational symmetry. The ribose rings of most nucleotides take S (close to C2'-endo) puckering, which is unusual for an RNA. K(+) can increase the stability of this quadruplex structure; the number of bound K(+) was estimated from the results of the titration experiment. Besides G:G and G:A mismatches, a network of hydrogen bonds including O4'-NH(2) and C-H..O hydrogen bonds, and the extensive base stacking contribute to the high thermodynamic stability of R14. Our results could provide the stereochemical and thermodynamic basis for elucidating the biological role of the GGAGG-containing RNA segments abundantly existing in various RNAs. Relevance to quadruplex-mediated mRNA-FMRP binding and HIV-1 genome RNA dimerization is discussed." @default.
• W2005309151 created "2016-06-24" @default.
• W2005309151 creator A5044301848 @default.
• W2005309151 creator A5055089277 @default.
• W2005309151 creator A5064657771 @default.
• W2005309151 creator A5064991330 @default.
• W2005309151 date "2002-10-01" @default.
• W2005309151 modified "2023-10-16" @default.
• W2005309151 title "A Dimeric RNA Quadruplex Architecture Comprised of Two G:G(:A):G:G(:A) Hexads, G:G:G:G Tetrads and UUUU Loops" @default.
• W2005309151 cites W1969089197 @default.
• W2005309151 cites W1969270088 @default.
• W2005309151 cites W1969744746 @default.
• W2005309151 cites W1969757241 @default.
• W2005309151 cites W1971135765 @default.
• W2005309151 cites W1972459558 @default.
• W2005309151 cites W1973382304 @default.
• W2005309151 cites W1973851418 @default.
• W2005309151 cites W1980779739 @default.
• W2005309151 cites W1986648841 @default.
• W2005309151 cites W1987046124 @default.
• W2005309151 cites W1993844842 @default.
• W2005309151 cites W1996248086 @default.
• W2005309151 cites W1997836836 @default.
• W2005309151 cites W2000274610 @default.
• W2005309151 cites W2000977546 @default.
• W2005309151 cites W2004116872 @default.
• W2005309151 cites W2005493974 @default.
• W2005309151 cites W2007812774 @default.
• W2005309151 cites W2011428226 @default.
• W2005309151 cites W2011585520 @default.
• W2005309151 cites W2011612347 @default.
• W2005309151 cites W2011844193 @default.
• W2005309151 cites W2015528782 @default.
• W2005309151 cites W2018884762 @default.
• W2005309151 cites W2021876859 @default.
• W2005309151 cites W2023436395 @default.
• W2005309151 cites W2029081636 @default.
• W2005309151 cites W2034064574 @default.
• W2005309151 cites W2045192978 @default.
• W2005309151 cites W2051299912 @default.
• W2005309151 cites W2051520616 @default.
• W2005309151 cites W2054053883 @default.
• W2005309151 cites W2056565971 @default.
• W2005309151 cites W2056687601 @default.
• W2005309151 cites W2060993373 @default.
• W2005309151 cites W2068167761 @default.
• W2005309151 cites W2074770586 @default.
• W2005309151 cites W2075005664 @default.
• W2005309151 cites W2078428995 @default.
• W2005309151 cites W2079057579 @default.
• W2005309151 cites W2079991869 @default.
• W2005309151 cites W2089583362 @default.
• W2005309151 cites W2090908102 @default.
• W2005309151 cites W2094690099 @default.
• W2005309151 cites W2098756736 @default.
• W2005309151 cites W2110811750 @default.
• W2005309151 cites W2123408329 @default.
• W2005309151 cites W2136794752 @default.
• W2005309151 cites W2137220579 @default.
• W2005309151 cites W2144175278 @default.
• W2005309151 cites W2144907241 @default.
• W2005309151 cites W2149482159 @default.
• W2005309151 cites W2154989302 @default.
• W2005309151 cites W2164151366 @default.
• W2005309151 cites W2169821755 @default.
• W2005309151 cites W2396589048 @default.
• W2005309151 cites W4243831105 @default.
• W2005309151 doi "https://doi.org/10.1016/s0022-2836(02)00876-8" @default.
• W2005309151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12367521" @default.
• W2005309151 hasPublicationYear "2002" @default.
• W2005309151 type Work @default.
• W2005309151 sameAs 2005309151 @default.
• W2005309151 citedByCount "68" @default.
• W2005309151 countsByYear W20053091512012 @default.
• W2005309151 countsByYear W20053091512013 @default.
• W2005309151 countsByYear W20053091512014 @default.
• W2005309151 countsByYear W20053091512015 @default.
• W2005309151 countsByYear W20053091512016 @default.
• W2005309151 countsByYear W20053091512017 @default.
• W2005309151 countsByYear W20053091512018 @default.
• W2005309151 countsByYear W20053091512019 @default.
• W2005309151 countsByYear W20053091512020 @default.
• W2005309151 countsByYear W20053091512021 @default.
• W2005309151 countsByYear W20053091512022 @default.
• W2005309151 countsByYear W20053091512023 @default.
• W2005309151 crossrefType "journal-article" @default.
• W2005309151 hasAuthorship W2005309151A5044301848 @default.
• W2005309151 hasAuthorship W2005309151A5055089277 @default.
• W2005309151 hasAuthorship W2005309151A5064657771 @default.
• W2005309151 hasAuthorship W2005309151A5064991330 @default.
• W2005309151 hasConcept C104317684 @default.
• W2005309151 hasConcept C112887158 @default.
• W2005309151 hasConcept C121332964 @default.
• W2005309151 hasConcept C147727578 @default.
• W2005309151 hasConcept C178790620 @default.
• W2005309151 hasConcept C185581394 @default.
• W2005309151 hasConcept C185592680 @default.
• W2005309151 hasConcept C2780642029 @default.

• next