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- W2005321089 abstract "The few data available indicate that resting membrane potential (MP) of thyroid acinar cells is reduced in animals given thyrotropin or goitrogen in vivo. There-fore we measured MP in mouse thyroids in vitro with and without thyrotropin in the superfusate and studied the effects of LATS-IgG. Potential was measured by use of glass micro-electrodes that had a tip resistance of 15–35 MΩ and a tip diameter of less than 1 μ. Intracellular potential was −39.1 mV ± 0.3 (SD) for 423 measurements; potential was linearly less negative with increasing log [K+], approximately 23 mV per ten-fold change in [K+]. There was depolarization with lowering of temperature or superfusion with 10−4 ouabain or 5 × 10−4 M dinitrophenol and in thyroids from mice given low-iodine diet for nine days. Superfusion with thyrotropin of glands with iodine labelled with 125I resulted in enhanced release of TCA-soluble radioactivity. Similar glands showed a reduced MP in response to superfusion with either thyrotropin (10 mU./ml.) or LATS-IgG solutions, there being no effect of solvent (1% human serum albumin) or normal human IgG. The effects of both thyrotropin and LATS-IgG appeared promptly and the potential returned to normal in both instances within 10 minutes of changing to control superfusing buffer. Conclusions are that depolarization of thyroid cell membrane is a prompt in vitro response to either thyrotropin or LATS; repolarization occurs rapidly after removal of the stimulators, indicating no persistence of the effect of LATS, relative to that of thyrotropin." @default.
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- W2005321089 title "In vitro influence of thyrotropin or long-acting thyroid stimulator on mouse thyroid membrane potential" @default.
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- W2005321089 doi "https://doi.org/10.1016/0026-0495(70)90070-3" @default.
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