FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005330710> ?p ?o ?g. }

• W2005330710 endingPage "G987" @default.
• W2005330710 startingPage "G976" @default.
• W2005330710 abstract "Wound healing of the gastrointestinal mucosa is essential for the maintenance of gut homeostasis and integrity. Enteric glial cells play a major role in regulating intestinal barrier function, but their role in mucosal barrier repair remains unknown. The impact of conditional ablation of enteric glia on dextran sodium sulfate (DSS)-induced mucosal damage and on healing of diclofenac-induced mucosal ulcerations was evaluated in vivo in GFAP-HSVtk transgenic mice. A mechanically induced model of intestinal wound healing was developed to study glial-induced epithelial restitution. Glial-epithelial signaling mechanisms were analyzed by using pharmacological inhibitors, neutralizing antibodies, and genetically engineered intestinal epithelial cells. Enteric glial cells were shown to be abundant in the gut mucosa, where they associate closely with intestinal epithelial cells as a distinct cell population from myofibroblasts. Conditional ablation of enteric glia worsened mucosal damage after DSS treatment and significantly delayed mucosal wound healing following diclofenac-induced small intestinal enteropathy in transgenic mice. Enteric glial cells enhanced epithelial restitution and cell spreading in vitro. These enhanced repair processes were reproduced by use of glial-conditioned media, and soluble proEGF was identified as a secreted glial mediator leading to consecutive activation of epidermal growth factor receptor and focal adhesion kinase signaling pathways in intestinal epithelial cells. Our study shows that enteric glia represent a functionally important cellular component of the intestinal epithelial barrier microenvironment and that the disruption of this cellular network attenuates the mucosal healing process." @default.
• W2005330710 created "2016-06-24" @default.
• W2005330710 creator A5004900328 @default.
• W2005330710 creator A5008207660 @default.
• W2005330710 creator A5014497378 @default.
• W2005330710 creator A5035913487 @default.
• W2005330710 creator A5036594737 @default.
• W2005330710 creator A5037511457 @default.
• W2005330710 creator A5044356368 @default.
• W2005330710 creator A5047448446 @default.
• W2005330710 date "2011-06-01" @default.
• W2005330710 modified "2023-09-25" @default.
• W2005330710 title "Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF" @default.
• W2005330710 cites W1510735029 @default.
• W2005330710 cites W1663066078 @default.
• W2005330710 cites W1901598508 @default.
• W2005330710 cites W1967699571 @default.
• W2005330710 cites W1968476355 @default.
• W2005330710 cites W1982811147 @default.
• W2005330710 cites W1992040739 @default.
• W2005330710 cites W1996912527 @default.
• W2005330710 cites W1997280251 @default.
• W2005330710 cites W2000793260 @default.
• W2005330710 cites W2008752643 @default.
• W2005330710 cites W2010433707 @default.
• W2005330710 cites W2015541518 @default.
• W2005330710 cites W2017773820 @default.
• W2005330710 cites W2018815492 @default.
• W2005330710 cites W2021495173 @default.
• W2005330710 cites W2021858341 @default.
• W2005330710 cites W2032123628 @default.
• W2005330710 cites W2041618415 @default.
• W2005330710 cites W2044895919 @default.
• W2005330710 cites W2059127937 @default.
• W2005330710 cites W2068472022 @default.
• W2005330710 cites W2074409981 @default.
• W2005330710 cites W2083034122 @default.
• W2005330710 cites W2083047615 @default.
• W2005330710 cites W2085062842 @default.
• W2005330710 cites W2090776773 @default.
• W2005330710 cites W2091858438 @default.
• W2005330710 cites W2099941593 @default.
• W2005330710 cites W2107217007 @default.
• W2005330710 cites W2107744185 @default.
• W2005330710 cites W2117734033 @default.
• W2005330710 cites W2140929617 @default.
• W2005330710 cites W2151411980 @default.
• W2005330710 cites W2156272127 @default.
• W2005330710 cites W2171246715 @default.
• W2005330710 cites W2171561168 @default.
• W2005330710 cites W2341408723 @default.
• W2005330710 cites W3192790212 @default.
• W2005330710 cites W4243070338 @default.
• W2005330710 cites W2025296191 @default.
• W2005330710 doi "https://doi.org/10.1152/ajpgi.00427.2010" @default.
• W2005330710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3119120" @default.
• W2005330710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21350188" @default.
• W2005330710 hasPublicationYear "2011" @default.
• W2005330710 type Work @default.
• W2005330710 sameAs 2005330710 @default.
• W2005330710 citedByCount "115" @default.
• W2005330710 countsByYear W20053307102012 @default.
• W2005330710 countsByYear W20053307102013 @default.
• W2005330710 countsByYear W20053307102014 @default.
• W2005330710 countsByYear W20053307102015 @default.
• W2005330710 countsByYear W20053307102016 @default.
• W2005330710 countsByYear W20053307102017 @default.
• W2005330710 countsByYear W20053307102018 @default.
• W2005330710 countsByYear W20053307102019 @default.
• W2005330710 countsByYear W20053307102020 @default.
• W2005330710 countsByYear W20053307102021 @default.
• W2005330710 countsByYear W20053307102022 @default.
• W2005330710 countsByYear W20053307102023 @default.
• W2005330710 crossrefType "journal-article" @default.
• W2005330710 hasAuthorship W2005330710A5004900328 @default.
• W2005330710 hasAuthorship W2005330710A5008207660 @default.
• W2005330710 hasAuthorship W2005330710A5014497378 @default.
• W2005330710 hasAuthorship W2005330710A5035913487 @default.
• W2005330710 hasAuthorship W2005330710A5036594737 @default.
• W2005330710 hasAuthorship W2005330710A5037511457 @default.
• W2005330710 hasAuthorship W2005330710A5044356368 @default.
• W2005330710 hasAuthorship W2005330710A5047448446 @default.
• W2005330710 hasBestOaLocation W20053307102 @default.
• W2005330710 hasConcept C126322002 @default.
• W2005330710 hasConcept C142724271 @default.
• W2005330710 hasConcept C203014093 @default.
• W2005330710 hasConcept C2780269544 @default.
• W2005330710 hasConcept C3019368612 @default.
• W2005330710 hasConcept C502942594 @default.
• W2005330710 hasConcept C71924100 @default.
• W2005330710 hasConcept C86803240 @default.
• W2005330710 hasConcept C95444343 @default.
• W2005330710 hasConceptScore W2005330710C126322002 @default.
• W2005330710 hasConceptScore W2005330710C142724271 @default.
• W2005330710 hasConceptScore W2005330710C203014093 @default.
• W2005330710 hasConceptScore W2005330710C2780269544 @default.
• W2005330710 hasConceptScore W2005330710C3019368612 @default.
• W2005330710 hasConceptScore W2005330710C502942594 @default.

• next