Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005331490> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2005331490 endingPage "199" @default.
- W2005331490 startingPage "194" @default.
- W2005331490 abstract "To investigate the possible relation between HLA antigens and either favourable clinical response or toxic reaction to two different gold compounds, aurothioglucose and auranofin, a new orally absorbable gold compound, we studied 50 patients with rheumatoid arthritis prospectively. Of the 25 aurothioglucose-treated patients, response to treatment could not be evaluated in four patients because of early toxicity. Nine patients showed an excellent response, while 12 were moderate or non-responders. Four of the 9 excellent responders were HLA-DR3 positive, but none of the 12 moderate or non-responders possessed this antigen (P less than 0.025). In accordance with previous reports HLA-DR3 was found more frequently in patients developing toxicity on aurothioglucose than in those who did not (RR = 5.6). No association was found between HLA antigens and favourable clinical response in 25 auranofin-treated patients. Two of them showed a severe adverse reaction, neither of them being DR3-positive. HLA-DR3 positivity is associated not only with drug toxicity, but also with excellent respondership to aurothioglucose treatment." @default.
- W2005331490 created "2016-06-24" @default.
- W2005331490 creator A5031550989 @default.
- W2005331490 creator A5044475682 @default.
- W2005331490 creator A5047364022 @default.
- W2005331490 creator A5076651742 @default.
- W2005331490 date "2008-12-11" @default.
- W2005331490 modified "2023-09-26" @default.
- W2005331490 title "Association of HLA antigens, toxic reactions and therapeutic response to auranofin and aurothioglucose in patients with rheumatoid arthritis" @default.
- W2005331490 cites W1973225343 @default.
- W2005331490 cites W2004080717 @default.
- W2005331490 cites W2018467376 @default.
- W2005331490 cites W2067210148 @default.
- W2005331490 cites W2086591805 @default.
- W2005331490 cites W2091943129 @default.
- W2005331490 cites W2110241655 @default.
- W2005331490 cites W2340851041 @default.
- W2005331490 cites W4249398224 @default.
- W2005331490 doi "https://doi.org/10.1111/j.1399-0039.1983.tb01191.x" @default.
- W2005331490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6415865" @default.
- W2005331490 hasPublicationYear "2008" @default.
- W2005331490 type Work @default.
- W2005331490 sameAs 2005331490 @default.
- W2005331490 citedByCount "37" @default.
- W2005331490 countsByYear W20053314902012 @default.
- W2005331490 countsByYear W20053314902014 @default.
- W2005331490 countsByYear W20053314902023 @default.
- W2005331490 crossrefType "journal-article" @default.
- W2005331490 hasAuthorship W2005331490A5031550989 @default.
- W2005331490 hasAuthorship W2005331490A5044475682 @default.
- W2005331490 hasAuthorship W2005331490A5047364022 @default.
- W2005331490 hasAuthorship W2005331490A5076651742 @default.
- W2005331490 hasConcept C126322002 @default.
- W2005331490 hasConcept C147483822 @default.
- W2005331490 hasConcept C188280979 @default.
- W2005331490 hasConcept C203014093 @default.
- W2005331490 hasConcept C2776243873 @default.
- W2005331490 hasConcept C2777575956 @default.
- W2005331490 hasConcept C2780035454 @default.
- W2005331490 hasConcept C29730261 @default.
- W2005331490 hasConcept C71924100 @default.
- W2005331490 hasConcept C90924648 @default.
- W2005331490 hasConcept C98274493 @default.
- W2005331490 hasConceptScore W2005331490C126322002 @default.
- W2005331490 hasConceptScore W2005331490C147483822 @default.
- W2005331490 hasConceptScore W2005331490C188280979 @default.
- W2005331490 hasConceptScore W2005331490C203014093 @default.
- W2005331490 hasConceptScore W2005331490C2776243873 @default.
- W2005331490 hasConceptScore W2005331490C2777575956 @default.
- W2005331490 hasConceptScore W2005331490C2780035454 @default.
- W2005331490 hasConceptScore W2005331490C29730261 @default.
- W2005331490 hasConceptScore W2005331490C71924100 @default.
- W2005331490 hasConceptScore W2005331490C90924648 @default.
- W2005331490 hasConceptScore W2005331490C98274493 @default.
- W2005331490 hasIssue "3" @default.
- W2005331490 hasLocation W20053314901 @default.
- W2005331490 hasLocation W20053314902 @default.
- W2005331490 hasOpenAccess W2005331490 @default.
- W2005331490 hasPrimaryLocation W20053314901 @default.
- W2005331490 hasRelatedWork W147775443 @default.
- W2005331490 hasRelatedWork W1963646178 @default.
- W2005331490 hasRelatedWork W1993419001 @default.
- W2005331490 hasRelatedWork W2008949385 @default.
- W2005331490 hasRelatedWork W2019101100 @default.
- W2005331490 hasRelatedWork W2053177727 @default.
- W2005331490 hasRelatedWork W2072493081 @default.
- W2005331490 hasRelatedWork W2469596609 @default.
- W2005331490 hasRelatedWork W2514212217 @default.
- W2005331490 hasRelatedWork W2540336298 @default.
- W2005331490 hasVolume "22" @default.
- W2005331490 isParatext "false" @default.
- W2005331490 isRetracted "false" @default.
- W2005331490 magId "2005331490" @default.
- W2005331490 workType "article" @default.