Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005332052> ?p ?o ?g. }
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- W2005332052 startingPage "294" @default.
- W2005332052 abstract "Mucocutaneous candidiasis and dermatophyte infections occur either in isolation or alongside other symptoms in patients with various primary immunodeficiency diseases with diverse genetic defects, which result in impaired IL-17 immunity, IL-22 immunity, or both. In patients with chronic mucocutaneous candidiasis, disease-associated polymorphisms in DECTIN1 act on the level of fungal recognition, whereas mutations in caspase recruitment domain-containing protein 9 (CARD9) disturb the subsequent spleen tyrosine kinase 2-CARD9/BCL10/MALT1-driven signaling cascade, impairing nuclear factor κB-mediated maturation of antigen-presenting cells and priming of naive T cells to differentiate into the T(H)17 cell lineage. T(H)17-priming cytokines signal through the transcription factor signal transducer and activator of transcription (STAT) 3, which in turn induces the T(H)17 lineage-determining transcription factor retinoic acid-related orphan receptor γt. Dominant-negative mutations in STAT3 result in reduced numbers of T(H)17 cells, causing localized candidiasis in patients with hyper-IgE syndrome. In patients with chronic mucocutaneous candidiasis, gain-of-function STAT1 mutations shift the cellular response toward T(H)17 cell-inhibiting cytokines. T(H)17 cells secrete IL-17 and IL-22, which are cytokines with potent antifungal properties, including production of antimicrobial peptides and activation and recruitment of neutrophils. Neutrophils mediate microbial killing through phagocytosis, degranulation, and neutrophil extracellular traps. Mutations in IL17F and IL17R in patients with chronic mucocutaneous candidiasis, as well as neutralizing autoantibodies against IL-17 and IL-22 in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, directly impair IL-17 and IL-22 immunity." @default.
- W2005332052 created "2016-06-24" @default.
- W2005332052 creator A5069080143 @default.
- W2005332052 creator A5070228992 @default.
- W2005332052 date "2012-02-01" @default.
- W2005332052 modified "2023-10-09" @default.
- W2005332052 title "Mendelian traits causing susceptibility to mucocutaneous fungal infections in human subjects" @default.
- W2005332052 cites W1519886765 @default.
- W2005332052 cites W1564622887 @default.
- W2005332052 cites W1586923479 @default.
- W2005332052 cites W1697354033 @default.
- W2005332052 cites W1887296783 @default.
- W2005332052 cites W1904721555 @default.
- W2005332052 cites W1931748660 @default.
- W2005332052 cites W1952097885 @default.
- W2005332052 cites W1956405455 @default.
- W2005332052 cites W1964465182 @default.
- W2005332052 cites W1965206234 @default.
- W2005332052 cites W1968683200 @default.
- W2005332052 cites W1971307936 @default.
- W2005332052 cites W1974366841 @default.
- W2005332052 cites W1978668479 @default.
- W2005332052 cites W1984747726 @default.
- W2005332052 cites W1987628377 @default.
- W2005332052 cites W1988820663 @default.
- W2005332052 cites W1989880051 @default.
- W2005332052 cites W1990530060 @default.
- W2005332052 cites W1992881199 @default.
- W2005332052 cites W1995928670 @default.
- W2005332052 cites W1999363201 @default.
- W2005332052 cites W2002836781 @default.
- W2005332052 cites W2003055036 @default.
- W2005332052 cites W2004186675 @default.
- W2005332052 cites W2004336750 @default.
- W2005332052 cites W2005942970 @default.
- W2005332052 cites W2008924149 @default.
- W2005332052 cites W2009013529 @default.
- W2005332052 cites W2011882192 @default.
- W2005332052 cites W2013277175 @default.
- W2005332052 cites W2013710888 @default.
- W2005332052 cites W2016003115 @default.
- W2005332052 cites W2020917300 @default.
- W2005332052 cites W2024490058 @default.
- W2005332052 cites W2024755223 @default.
- W2005332052 cites W2028998404 @default.
- W2005332052 cites W2031213205 @default.
- W2005332052 cites W2032529529 @default.
- W2005332052 cites W2034453891 @default.
- W2005332052 cites W2036619734 @default.
- W2005332052 cites W2040773127 @default.
- W2005332052 cites W2040890511 @default.
- W2005332052 cites W2042316672 @default.
- W2005332052 cites W2047949586 @default.
- W2005332052 cites W2050152285 @default.
- W2005332052 cites W2050563366 @default.
- W2005332052 cites W2051018333 @default.
- W2005332052 cites W2052659821 @default.
- W2005332052 cites W2064400534 @default.
- W2005332052 cites W2065540590 @default.
- W2005332052 cites W2066222426 @default.
- W2005332052 cites W2070171027 @default.
- W2005332052 cites W2072263302 @default.
- W2005332052 cites W2074719574 @default.
- W2005332052 cites W2082390177 @default.
- W2005332052 cites W2086105638 @default.
- W2005332052 cites W2086831075 @default.
- W2005332052 cites W2091451666 @default.
- W2005332052 cites W2093785176 @default.
- W2005332052 cites W2095601290 @default.
- W2005332052 cites W2100585044 @default.
- W2005332052 cites W2101524137 @default.
- W2005332052 cites W2104497596 @default.
- W2005332052 cites W2104722369 @default.
- W2005332052 cites W2107235439 @default.
- W2005332052 cites W2108585076 @default.
- W2005332052 cites W2109747408 @default.
- W2005332052 cites W2112032339 @default.
- W2005332052 cites W2113576692 @default.
- W2005332052 cites W2114043064 @default.
- W2005332052 cites W2115055179 @default.
- W2005332052 cites W2115779634 @default.
- W2005332052 cites W2116516945 @default.
- W2005332052 cites W2119504328 @default.
- W2005332052 cites W2123093300 @default.
- W2005332052 cites W2125573161 @default.
- W2005332052 cites W2129629034 @default.
- W2005332052 cites W2130868872 @default.
- W2005332052 cites W2133449490 @default.
- W2005332052 cites W2134900294 @default.
- W2005332052 cites W2135386119 @default.
- W2005332052 cites W2137176031 @default.
- W2005332052 cites W2138694950 @default.
- W2005332052 cites W2139008734 @default.
- W2005332052 cites W2140333814 @default.
- W2005332052 cites W2142017607 @default.
- W2005332052 cites W2142127956 @default.
- W2005332052 cites W2143218174 @default.
- W2005332052 cites W2144280353 @default.