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• W2005337633 abstract "Combining experimental evolution with whole-genome resequencing is a promising new strategy for investigating the dynamics of evolutionary change. Published studies that have resequenced laboratory-selected populations of sexual organisms have typically focused on populations sampled at the end of an evolution experiment. These studies have attempted to associate particular alleles with phenotypic change and attempted to distinguish between different theoretical models of adaptation. However, neither the population used to initiate the experiment nor multiple time points sampled during the evolutionary trajectory are generally available for examination. In this issue of Molecular Ecology, Orozco-terWengel et al. (2012) take a significant step forward by estimating genome-wide allele frequencies at the start, 15 generations into and at the end of a 37-generation Drosophila experimental evolution study. The authors identify regions of the genome that have responded to laboratory selection and describe the temporal dynamics of allele frequency change. They identify two common trajectories for putatively adaptive alleles: alleles either gradually increase in frequency throughout the entire 37 generations or alleles plateau at a new frequency by generation 15. The identification of complex trajectories of alleles under selection contributes to a growing body of literature suggesting that simple models of adaptation, whereby beneficial alleles arise and increase in frequency unimpeded until they become fixed, may not adequately describe short-term response to selection." @default.
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• W2005337633 date "2012-10-01" @default.
• W2005337633 modified "2023-09-27" @default.
• W2005337633 title "What paths do advantageous alleles take during short-term evolutionary change?" @default.
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• W2005337633 doi "https://doi.org/10.1111/j.1365-294x.2012.05745.x" @default.
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