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- W2005341722 abstract "From 1972 to 1977, 162 patients were treated with definitive radiotherapy for the underlying unresectable non-small-cell bronchogenic carcinoma by a radiotherapeutic technique that had sequentially evolved from a low-dose (40–45 gray) small-volume approach (AP-PA POP) to a high-dose (60–64 gray) large-volume en-bloc approach (AP-PA POP plus AP-RPO-LPO) which included the primary tumor and the entire regional lymphatics including both supraclavicular areas. Median survival and short-term survival up to 1.5 years were independent of radiation doses (40–64 gray) and target volumes studies. However, long-term survival ⩾ 2 years was radiation-dose and target-volume dependent: actuarial survival 36% and 28% vs. 10% and 3% for the high-dose (60–64 gray) en-bloc approach vs. Low-dose (40–45 gray) small-volume radiotherapy at 2 and 3 years, respectively, with a minimum follow-up of 2 years, P < 0.05. Actuarial five-year survival rate 7.5% was obtained with radiation dose ⩾ 50 gray. However, there was no five-year survivor among patients who were treated with radiation dose < 50 gray. Local tumor control is radiation-dose dependent: local tumor control rates at ⩾ 18 months were 76% vs. 29% by 56–64 gray vs. 40–49 gray, respectively, P < 0.05. The patterns of failure appeared to be tumor-histology dependent; for squamous cell carcinoma, the primary and regional lymphatic areas are the most common sites of failure, and for adenocarcinoma, it is the brain or bone. The high-dose en-bloc radiotherapy has been very well tolerated; 5% (4/80) incidence of symptomatic pneumonitis has been observed." @default.
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- W2005341722 date "1981-07-01" @default.
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- W2005341722 title "Improved survival of patients with unresectable non-small-cell bronchogenic carcinoma by an innovated high-doseEn-Bloc radiotherapeutic approach" @default.
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- W2005341722 doi "https://doi.org/10.1002/1097-0142(19810701)48:1<101::aid-cncr2820480120>3.0.co;2-s" @default.
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