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- W2005341915 abstract "A new water-soluble, salen [salen = bis(salicylidene) ethylenediamine]-based ligand, 3 was developed. Two of the metal complexes of this ligand, i.e., 3a, [Mn(III)] and 3b, [Ni(II)], in the presence of cooxidant magnesium monoperoxyphthalate (MMPP) cleaved plasmid DNA pTZ19R efficiently and rapidly at a concentration approximately 1 microM. In contrast, under comparable conditions, other metal complexes 3c, [Cu(II)] or 3d, [Cr(III)] could not induce any significant DNA nicking. The findings with Ni(II) complex suggest that the DNA cleavage processes can be modulated by the disposition of charges around the ligand." @default.
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- W2005341915 date "1996-09-01" @default.
- W2005341915 modified "2023-10-12" @default.
- W2005341915 title "Metal-ion-dependent oxidative DNA cleavage by transition metal complexes of a new water-soluble salen derivative" @default.
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- W2005341915 doi "https://doi.org/10.1016/0162-0134(95)00228-6" @default.
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