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- W2005342500 abstract "Contact sensitivity (allergic contact dermatitis) to bis(tri-n-butyltin) oxide (TBTO) was demonstrated in the mouse. TBTO (in an acetone: olive oil vehicle) or acetone: olive oil alone (as a control) were applied to the shaved flank under an occlusive patch and animals were challenged on the dorsum of the car 6 days later. Ear swelling was then measured using an engineer's micrometer, 2, 24, 48 or 72 h thereafter. Significant differences in ear swelling between control and TBTO-sensitized animals urn-found 24 h after challenge; thereafter the elicitation reaction declined rapidly whilst irritant swelling in control animals increased. Maximal elicitation of TBTO sensitivity could only lie elicited by concern rat ions of TBTO that caused irritation. In a separate experiment, u single application of TBTO to the ears of naive animals provoked increases in auricular lymph node weight, cell yield and proliferation of lymph node cells during overnight culture. These data support the conclusion that TBTO is a contact sensitizer and illustrate the potential usefulness of the quantitative methods of contact sensitivity assessment winch have been developed in the mouse." @default.
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- W2005342500 date "1991-03-01" @default.
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- W2005342500 title "Contact sensitivity (allergic contact dermatitis) to bis(tri-n-butyltin) oxide in mice" @default.
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- W2005342500 doi "https://doi.org/10.1111/j.1600-0536.1991.tb01700.x" @default.
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