FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005350078> ?p ?o ?g. }

• W2005350078 endingPage "24" @default.
• W2005350078 startingPage "21" @default.
• W2005350078 abstract "Recently the neuronal toxicity of intracellular amyloid β (iAβ) in Alzheimer's disease is attracting more and more attention. The present study explored the effects of curcumin on the iAβ-induced toxicity in primary cultured rat prefrontal cortical neurons. The cell viability of primary cultured prefrontal cortical neurons decreased significantly after virus driven transfection of Aβ from 1 day to 7 days. Interestingly, administration of 1 μM, 10 μM or 20 μM of curcumin significantly inhibited the iAβ-induced toxicity in primary cultured rat prefrontal cortical neurons tested by MTT and LDH release assays. We further studied the involvements of apoptotic or neuroprotective pathway proteins in curcumin protection against iAβ-induced cytotoxicity in primary cultured rat prefrontal cortical neurons. The results demonstrated that the contents of activated caspase-3 increased significantly by iAβ, while curcumin significantly inhibited the iAβ-induced increases of activated caspase-3 tested by Western blot. And the contents of p-AKT decreased significantly after iAβ treatment, while administration of curcumin significantly inhibited the iAβ-induced decreases in the contents of p-AKT. The results suggest that curcumin may play a protective effect in primary cultured rat prefrontal cortical neurons against iAβ-induced cytotoxicity, and both AKT and caspase-3 are involved in the curcumin-induced protective effects." @default.
• W2005350078 created "2016-06-24" @default.
• W2005350078 creator A5011838198 @default.
• W2005350078 creator A5031244438 @default.
• W2005350078 creator A5052627018 @default.
• W2005350078 date "2010-08-01" @default.
• W2005350078 modified "2023-10-17" @default.
• W2005350078 title "Potential protection of curcumin against intracellular amyloid β-induced toxicity in cultured rat prefrontal cortical neurons" @default.
• W2005350078 cites W1540436551 @default.
• W2005350078 cites W1602771322 @default.
• W2005350078 cites W1967464880 @default.
• W2005350078 cites W1969908475 @default.
• W2005350078 cites W1973276273 @default.
• W2005350078 cites W2006643658 @default.
• W2005350078 cites W2007922488 @default.
• W2005350078 cites W2010073511 @default.
• W2005350078 cites W2048695741 @default.
• W2005350078 cites W2051314670 @default.
• W2005350078 cites W2067531355 @default.
• W2005350078 cites W2076441911 @default.
• W2005350078 cites W2077651746 @default.
• W2005350078 cites W2084720032 @default.
• W2005350078 cites W2091899079 @default.
• W2005350078 cites W2101612148 @default.
• W2005350078 cites W2156156861 @default.
• W2005350078 cites W2157067671 @default.
• W2005350078 cites W2166486694 @default.
• W2005350078 cites W2170644095 @default.
• W2005350078 cites W2171539213 @default.
• W2005350078 cites W2309773444 @default.
• W2005350078 doi "https://doi.org/10.1016/j.neulet.2010.05.062" @default.
• W2005350078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20638958" @default.
• W2005350078 hasPublicationYear "2010" @default.
• W2005350078 type Work @default.
• W2005350078 sameAs 2005350078 @default.
• W2005350078 citedByCount "53" @default.
• W2005350078 countsByYear W20053500782012 @default.
• W2005350078 countsByYear W20053500782013 @default.
• W2005350078 countsByYear W20053500782014 @default.
• W2005350078 countsByYear W20053500782015 @default.
• W2005350078 countsByYear W20053500782016 @default.
• W2005350078 countsByYear W20053500782017 @default.
• W2005350078 countsByYear W20053500782018 @default.
• W2005350078 countsByYear W20053500782019 @default.
• W2005350078 countsByYear W20053500782020 @default.
• W2005350078 countsByYear W20053500782021 @default.
• W2005350078 countsByYear W20053500782022 @default.
• W2005350078 countsByYear W20053500782023 @default.
• W2005350078 crossrefType "journal-article" @default.
• W2005350078 hasAuthorship W2005350078A5011838198 @default.
• W2005350078 hasAuthorship W2005350078A5031244438 @default.
• W2005350078 hasAuthorship W2005350078A5052627018 @default.
• W2005350078 hasConcept C104317684 @default.
• W2005350078 hasConcept C109316439 @default.
• W2005350078 hasConcept C12519072 @default.
• W2005350078 hasConcept C169760540 @default.
• W2005350078 hasConcept C169900460 @default.
• W2005350078 hasConcept C178790620 @default.
• W2005350078 hasConcept C185592680 @default.
• W2005350078 hasConcept C190283241 @default.
• W2005350078 hasConcept C202751555 @default.
• W2005350078 hasConcept C25498285 @default.
• W2005350078 hasConcept C2776415932 @default.
• W2005350078 hasConcept C2778250585 @default.
• W2005350078 hasConcept C2781195155 @default.
• W2005350078 hasConcept C29730261 @default.
• W2005350078 hasConcept C31573885 @default.
• W2005350078 hasConcept C53227056 @default.
• W2005350078 hasConcept C55493867 @default.
• W2005350078 hasConcept C75217442 @default.
• W2005350078 hasConcept C79879829 @default.
• W2005350078 hasConcept C86803240 @default.
• W2005350078 hasConcept C95444343 @default.
• W2005350078 hasConcept C98274493 @default.
• W2005350078 hasConceptScore W2005350078C104317684 @default.
• W2005350078 hasConceptScore W2005350078C109316439 @default.
• W2005350078 hasConceptScore W2005350078C12519072 @default.
• W2005350078 hasConceptScore W2005350078C169760540 @default.
• W2005350078 hasConceptScore W2005350078C169900460 @default.
• W2005350078 hasConceptScore W2005350078C178790620 @default.
• W2005350078 hasConceptScore W2005350078C185592680 @default.
• W2005350078 hasConceptScore W2005350078C190283241 @default.
• W2005350078 hasConceptScore W2005350078C202751555 @default.
• W2005350078 hasConceptScore W2005350078C25498285 @default.
• W2005350078 hasConceptScore W2005350078C2776415932 @default.
• W2005350078 hasConceptScore W2005350078C2778250585 @default.
• W2005350078 hasConceptScore W2005350078C2781195155 @default.
• W2005350078 hasConceptScore W2005350078C29730261 @default.
• W2005350078 hasConceptScore W2005350078C31573885 @default.
• W2005350078 hasConceptScore W2005350078C53227056 @default.
• W2005350078 hasConceptScore W2005350078C55493867 @default.
• W2005350078 hasConceptScore W2005350078C75217442 @default.
• W2005350078 hasConceptScore W2005350078C79879829 @default.
• W2005350078 hasConceptScore W2005350078C86803240 @default.
• W2005350078 hasConceptScore W2005350078C95444343 @default.
• W2005350078 hasConceptScore W2005350078C98274493 @default.
• W2005350078 hasIssue "1" @default.
• W2005350078 hasLocation W20053500781 @default.

• next