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- W2005352733 abstract "Phase I/II trials of new cancer therapies are designed to determine safety, efficacy and the optimal regimen for treatment. In order to uphold the principle that ‘the interests of the subject must prevail over the interests of science and society’ as laid down in the Declaration of Helsinki the effects of these trials on quality of life must be determined. Antibody-targeted therapies are a new form of cancer therapy designed to selectively deliver cytotoxic agents to cancer cells. Twenty-four patients with advanced colorectal cancer were enrolled into trials of three different treatment modalities based on this theme. Quality of life was measured using the Hospital Anxiety and Depression Scale and the Rotterdam Symptom Checklist prior to and 4 weeks after treatment. The Common Toxicity Criteria of the NCI were used to assess treatment related toxicity. There was no significant difference between pre- and post-treatment scores for all three treatment modalities. There was also no significant correlations between toxicity and physical or psychological morbidity. We suggest that the quality of life of patients undergoing phase I/II clinical trials with antibody targeted therapies for metastatic colorectal carcinoma was not adversly affected. We feel that in part this can be attributed to the high level and the intensity of support provided for the patients undergoing these treatments." @default.
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- W2005352733 date "1997-12-01" @default.
- W2005352733 modified "2023-10-17" @default.
- W2005352733 title "The importance of measuring quality of life in phase I/II trials of cancer therapy - the effects of antibody targeted therapy: part I" @default.
- W2005352733 doi "https://doi.org/10.1046/j.1365-2354.1997.00053.x" @default.
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