Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005357334> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2005357334 endingPage "434" @default.
- W2005357334 startingPage "427" @default.
- W2005357334 abstract "To identify the anticoagulant region of the phospholipase A2 (PLA2) from the Agkistrodon halys Pallas (class II), four mutants E53G, W70M, T56K, and D67K were produced according to the prediction from the crystal structure and the sequence comparison of the strong, weak and non-anticoagulant PLA2s. A test of blood clotting revealed that E53G and W70M had lost their effects on the blood clotting, while T56K and D67K had enhanced activity. The four residues are located on the same face in the tertiary structure of this enzyme. The result supported the prediction that there exists an anticoagulant region that is composed of some residues that are close to each other in tertiary structure to form a functional face. Keywords: ANTICOAGULANT ACTIVITY, BASIC PHOSPHOLIPASE, AGKISTRODON HALYS, T56K, D67K" @default.
- W2005357334 created "2016-06-24" @default.
- W2005357334 creator A5028401641 @default.
- W2005357334 creator A5037181214 @default.
- W2005357334 creator A5040320732 @default.
- W2005357334 creator A5051601002 @default.
- W2005357334 creator A5073887339 @default.
- W2005357334 date "2002-10-01" @default.
- W2005357334 modified "2023-09-27" @default.
- W2005357334 title "Functionally Important Residues for the Anticoagulant Activity of A Basic Phospholipase A2 from the Agkistrodon Halys Pallas" @default.
- W2005357334 doi "https://doi.org/10.2174/0929866023408580" @default.
- W2005357334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12370031" @default.
- W2005357334 hasPublicationYear "2002" @default.
- W2005357334 type Work @default.
- W2005357334 sameAs 2005357334 @default.
- W2005357334 citedByCount "8" @default.
- W2005357334 countsByYear W20053573342015 @default.
- W2005357334 countsByYear W20053573342016 @default.
- W2005357334 crossrefType "journal-article" @default.
- W2005357334 hasAuthorship W2005357334A5028401641 @default.
- W2005357334 hasAuthorship W2005357334A5037181214 @default.
- W2005357334 hasAuthorship W2005357334A5040320732 @default.
- W2005357334 hasAuthorship W2005357334A5051601002 @default.
- W2005357334 hasAuthorship W2005357334A5073887339 @default.
- W2005357334 hasConcept C126322002 @default.
- W2005357334 hasConcept C12927208 @default.
- W2005357334 hasConcept C181199279 @default.
- W2005357334 hasConcept C185592680 @default.
- W2005357334 hasConcept C2776551241 @default.
- W2005357334 hasConcept C2778205648 @default.
- W2005357334 hasConcept C2992598832 @default.
- W2005357334 hasConcept C55493867 @default.
- W2005357334 hasConcept C71924100 @default.
- W2005357334 hasConcept C86803240 @default.
- W2005357334 hasConceptScore W2005357334C126322002 @default.
- W2005357334 hasConceptScore W2005357334C12927208 @default.
- W2005357334 hasConceptScore W2005357334C181199279 @default.
- W2005357334 hasConceptScore W2005357334C185592680 @default.
- W2005357334 hasConceptScore W2005357334C2776551241 @default.
- W2005357334 hasConceptScore W2005357334C2778205648 @default.
- W2005357334 hasConceptScore W2005357334C2992598832 @default.
- W2005357334 hasConceptScore W2005357334C55493867 @default.
- W2005357334 hasConceptScore W2005357334C71924100 @default.
- W2005357334 hasConceptScore W2005357334C86803240 @default.
- W2005357334 hasIssue "5" @default.
- W2005357334 hasLocation W20053573341 @default.
- W2005357334 hasLocation W20053573342 @default.
- W2005357334 hasOpenAccess W2005357334 @default.
- W2005357334 hasPrimaryLocation W20053573341 @default.
- W2005357334 hasRelatedWork W2005357334 @default.
- W2005357334 hasRelatedWork W2035010930 @default.
- W2005357334 hasRelatedWork W2087236557 @default.
- W2005357334 hasRelatedWork W2115477213 @default.
- W2005357334 hasRelatedWork W2120919525 @default.
- W2005357334 hasRelatedWork W2231553588 @default.
- W2005357334 hasRelatedWork W2410779175 @default.
- W2005357334 hasRelatedWork W2418073713 @default.
- W2005357334 hasRelatedWork W2796188648 @default.
- W2005357334 hasRelatedWork W4226432793 @default.
- W2005357334 hasVolume "9" @default.
- W2005357334 isParatext "false" @default.
- W2005357334 isRetracted "false" @default.
- W2005357334 magId "2005357334" @default.
- W2005357334 workType "article" @default.