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- W2005360030 abstract "31P and 1H nuclear magnetic resonance spectroscopy were used to study the effects of ammonium on high-energy phosphates, intracellular pH and lactate in guinea pig cerebral cortex in vitro. In the presence of glucose, 1 mM ammonium caused an intracellular acidification by 0.2–0.3 pH units without a change in phosphocreatine/ATP (PCr/ATP) ratio, lactate concentration or oxygen uptake. At concentrations of 5 mM or greater, NH4+ caused an energy failure and an increase in tissue lactate, together with a drop in intracellular pH. A split in the inorganic phosphate resonance was observed during the exposure to both 20 mM NH4+ and 20 mM K+ indicating heterogeneity of the volume-averaged intracellular pH. Cortical brain slices incubated in the presence of 10 mM lactate maintained PCr/ATP ratio and intracellular pH at similar levels as in the presence of glucose, but 1 mM NH4+ caused a fall in PCr/ATP. Both 20 mM NH4+ and 20 mM K+ stimulated oxygen uptake of the preparation with glucose or lactate as substrate. These results show that the only acute effect of 1 mM NH4+ in the presence of glucose is an intracellular acidification whereas energetic consequences develop at high levels of this neurotoxic agent." @default.
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- W2005360030 date "1991-01-01" @default.
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- W2005360030 title "Effects of ammonium on energy metabolism and intracellular pH in guinea pig cerebral cortex studied by 31P and 1H nuclear magnetic resonance spectroscopy" @default.
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- W2005360030 doi "https://doi.org/10.1016/0197-0186(91)90067-n" @default.
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