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- W2005361208 endingPage "11922" @default.
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- W2005361208 abstract "A self-assembled pseudopolyrotaxane consisting of lactoside-displaying cyclodextrin (CD) “beads” threaded onto a linear polyviologen “string” was investigated for its ability to inhibit galectin-1-mediated T-cell agglutination. The CDs of the pseudopolyrotaxane are able to spin around the axis of the polymer chain as well as to move back and forth along its backbone to alter the presentation of its ligand. This supramolecular superstructure incorporates all the advantages of polymeric structures, such as the ability to span large distances, along with a distinctively dynamic presentation of its lactoside ligands to afford a neoglycoconjugate that can adjust to the relative stereochemistries of the lectin's binding sites. The pseudopolyrotaxane exhibited a valency-corrected 10-fold enhancement over native lactose in the agglutination assay, which was greater than the enhancements observed for lactoside-bearing trivalent glycoclusters and a lactoside-bearing chitosan polymer tested using the same assay. The experimental results indicate that supramolecular architectures, such as the pseudopolyrotaxane, provide tools for investigating protein−carbohydrate interactions." @default.
- W2005361208 created "2016-06-24" @default.
- W2005361208 creator A5015322042 @default.
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- W2005361208 creator A5041664332 @default.
- W2005361208 creator A5080323741 @default.
- W2005361208 creator A5089719740 @default.
- W2005361208 date "2004-09-01" @default.
- W2005361208 modified "2023-10-17" @default.
- W2005361208 title "A Self-Assembled Multivalent Pseudopolyrotaxane for Binding Galectin-1" @default.
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- W2005361208 doi "https://doi.org/10.1021/ja0491073" @default.
- W2005361208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15382926" @default.
- W2005361208 hasPublicationYear "2004" @default.