FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005364009> ?p ?o ?g. }

• W2005364009 endingPage "e1002185" @default.
• W2005364009 startingPage "e1002185" @default.
• W2005364009 abstract "Recent data shows that HIV-1 is characterised by variation in viral virulence factors that is heritable between infections, which suggests that viral virulence can be naturally selected at the population level. A trade-off between transmissibility and duration of infection appears to favour viruses of intermediate virulence. We developed a mathematical model to simulate the dynamics of putative viral genotypes that differ in their virulence. As a proxy for virulence, we use set-point viral load (SPVL), which is the steady density of viral particles in blood during asymptomatic infection. Mutation, the dependency of survival and transmissibility on SPVL, and host effects were incorporated into the model. The model was fitted to data to estimate unknown parameters, and was found to fit existing data well. The maximum likelihood estimates of the parameters produced a model in which SPVL converged from any initial conditions to observed values within 100-150 years of first emergence of HIV-1. We estimated the 1) host effect and 2) the extent to which the viral virulence genotype mutates from one infection to the next, and found a trade-off between these two parameters in explaining the variation in SPVL. The model confirms that evolution of virulence towards intermediate levels is sufficiently rapid for it to have happened in the early stages of the HIV epidemic, and confirms that existing viral loads are nearly optimal given the assumed constraints on evolution. The model provides a useful framework under which to examine the future evolution of HIV-1 virulence." @default.
• W2005364009 created "2016-06-24" @default.
• W2005364009 creator A5002192906 @default.
• W2005364009 creator A5006090253 @default.
• W2005364009 creator A5027792801 @default.
• W2005364009 creator A5075360503 @default.
• W2005364009 date "2011-10-13" @default.
• W2005364009 modified "2023-10-17" @default.
• W2005364009 title "Transmission Selects for HIV-1 Strains of Intermediate Virulence: A Modelling Approach" @default.
• W2005364009 cites W1914588449 @default.
• W2005364009 cites W1970444001 @default.
• W2005364009 cites W1973540642 @default.
• W2005364009 cites W1977900451 @default.
• W2005364009 cites W1980888764 @default.
• W2005364009 cites W1982721121 @default.
• W2005364009 cites W1995324211 @default.
• W2005364009 cites W2012139740 @default.
• W2005364009 cites W2019305960 @default.
• W2005364009 cites W2022762562 @default.
• W2005364009 cites W2023479104 @default.
• W2005364009 cites W2025590019 @default.
• W2005364009 cites W2025843191 @default.
• W2005364009 cites W2030659576 @default.
• W2005364009 cites W2031754540 @default.
• W2005364009 cites W2032099305 @default.
• W2005364009 cites W2034862708 @default.
• W2005364009 cites W2041795471 @default.
• W2005364009 cites W2044388759 @default.
• W2005364009 cites W2046518060 @default.
• W2005364009 cites W2049203607 @default.
• W2005364009 cites W2050129537 @default.
• W2005364009 cites W2053002571 @default.
• W2005364009 cites W2070649137 @default.
• W2005364009 cites W2082595989 @default.
• W2005364009 cites W2086146731 @default.
• W2005364009 cites W2091337695 @default.
• W2005364009 cites W2100430786 @default.
• W2005364009 cites W2109992855 @default.
• W2005364009 cites W2110406948 @default.
• W2005364009 cites W2121634437 @default.
• W2005364009 cites W2124364050 @default.
• W2005364009 cites W2124627199 @default.
• W2005364009 cites W2126515754 @default.
• W2005364009 cites W2126646926 @default.
• W2005364009 cites W2129060465 @default.
• W2005364009 cites W2135892144 @default.
• W2005364009 cites W2136526938 @default.
• W2005364009 cites W2136938923 @default.
• W2005364009 cites W2144420913 @default.
• W2005364009 cites W2145030314 @default.
• W2005364009 cites W2146634980 @default.
• W2005364009 cites W2148568544 @default.
• W2005364009 cites W2148970839 @default.
• W2005364009 cites W2149759731 @default.
• W2005364009 cites W2150412603 @default.
• W2005364009 cites W2152048324 @default.
• W2005364009 cites W2153778605 @default.
• W2005364009 cites W2159295367 @default.
• W2005364009 cites W2160226661 @default.
• W2005364009 cites W2162383408 @default.
• W2005364009 cites W2162727140 @default.
• W2005364009 cites W2163036286 @default.
• W2005364009 cites W2314461521 @default.
• W2005364009 doi "https://doi.org/10.1371/journal.pcbi.1002185" @default.
• W2005364009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3192807" @default.
• W2005364009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22022243" @default.
• W2005364009 hasPublicationYear "2011" @default.
• W2005364009 type Work @default.
• W2005364009 sameAs 2005364009 @default.
• W2005364009 citedByCount "37" @default.
• W2005364009 countsByYear W20053640092012 @default.
• W2005364009 countsByYear W20053640092013 @default.
• W2005364009 countsByYear W20053640092014 @default.
• W2005364009 countsByYear W20053640092015 @default.
• W2005364009 countsByYear W20053640092016 @default.
• W2005364009 countsByYear W20053640092017 @default.
• W2005364009 countsByYear W20053640092019 @default.
• W2005364009 countsByYear W20053640092020 @default.
• W2005364009 countsByYear W20053640092021 @default.
• W2005364009 countsByYear W20053640092023 @default.
• W2005364009 crossrefType "journal-article" @default.
• W2005364009 hasAuthorship W2005364009A5002192906 @default.
• W2005364009 hasAuthorship W2005364009A5006090253 @default.
• W2005364009 hasAuthorship W2005364009A5027792801 @default.
• W2005364009 hasAuthorship W2005364009A5075360503 @default.
• W2005364009 hasBestOaLocation W20053640091 @default.
• W2005364009 hasConcept C104317684 @default.
• W2005364009 hasConcept C121332964 @default.
• W2005364009 hasConcept C135763542 @default.
• W2005364009 hasConcept C141231307 @default.
• W2005364009 hasConcept C142462285 @default.
• W2005364009 hasConcept C144024400 @default.
• W2005364009 hasConcept C149923435 @default.
• W2005364009 hasConcept C159047783 @default.
• W2005364009 hasConcept C16683452 @default.
• W2005364009 hasConcept C198394728 @default.
• W2005364009 hasConcept C2522874641 @default.
• W2005364009 hasConcept C2908647359 @default.

• next