FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005366367> ?p ?o ?g. }

• W2005366367 endingPage "563" @default.
• W2005366367 startingPage "558" @default.
• W2005366367 abstract "Digestion of type I collagen with a collagenase-type protease yields a collagen tripeptide (Ctp) fraction comprising Gly-X-Y sequences that exhibit diverse biological activities. We previously demonstrated that Ctp inhibits the proliferation and migration of cultured aortic smooth muscle cells (SMCs) in vitro. These cells contribute to the pathogenesis of atherosclerosis and other cardiovascular diseases. In order to evaluate the effects of Ctp on atherosclerosis development in vivo, here we used the Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbit model of familial hypercholesterolemia to determine the effects of oral administration of Ctp for three months. Ctp induced a significant decrease in the area occupied by atherosclerotic plaques in the aorta and in the level of total serum cholesterol. The components of atherosclerotic plaques underwent distinct changes, including reduction in the populations of macrophages and SMCs and a significant decrease in the proportion of macrophages to SMCs. Ctp administration decreased the number of cells in plaques that expressed proliferating cell nuclear antigen and the number of cells with oxidative damage to DNA as indicated by 8-hydroxy-2'-deoxyguanine detection. These findings are the first to define the mechanism underlying the inhibitory effects of Ctp on atherosclerosis development in hypercholesterolemic rabbits, and suggest that Ctp provides an effective therapy for treating atherosclerosis." @default.
• W2005366367 created "2016-06-24" @default.
• W2005366367 creator A5004063791 @default.
• W2005366367 creator A5051109631 @default.
• W2005366367 creator A5059191212 @default.
• W2005366367 creator A5088687426 @default.
• W2005366367 date "2015-05-01" @default.
• W2005366367 modified "2023-09-30" @default.
• W2005366367 title "Effects of oral administration of tripeptides derived from type I collagen (collagen tripeptide) on atherosclerosis development in hypercholesterolemic rabbits" @default.
• W2005366367 cites W1968055952 @default.
• W2005366367 cites W1981905227 @default.
• W2005366367 cites W1992152105 @default.
• W2005366367 cites W1992415923 @default.
• W2005366367 cites W1993934912 @default.
• W2005366367 cites W1996866382 @default.
• W2005366367 cites W2011997615 @default.
• W2005366367 cites W2014463840 @default.
• W2005366367 cites W2024070385 @default.
• W2005366367 cites W2026363802 @default.
• W2005366367 cites W2045119323 @default.
• W2005366367 cites W2046308431 @default.
• W2005366367 cites W2049280895 @default.
• W2005366367 cites W2050165984 @default.
• W2005366367 cites W2054544120 @default.
• W2005366367 cites W2058229523 @default.
• W2005366367 cites W2058977087 @default.
• W2005366367 cites W2066963386 @default.
• W2005366367 cites W2071601398 @default.
• W2005366367 cites W2073751205 @default.
• W2005366367 cites W2101214961 @default.
• W2005366367 cites W2104330486 @default.
• W2005366367 cites W2121822802 @default.
• W2005366367 cites W2123388291 @default.
• W2005366367 cites W2135633069 @default.
• W2005366367 cites W2324841714 @default.
• W2005366367 cites W4296979652 @default.
• W2005366367 doi "https://doi.org/10.1016/j.jbiosc.2014.10.011" @default.
• W2005366367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25468425" @default.
• W2005366367 hasPublicationYear "2015" @default.
• W2005366367 type Work @default.
• W2005366367 sameAs 2005366367 @default.
• W2005366367 citedByCount "12" @default.
• W2005366367 countsByYear W20053663672016 @default.
• W2005366367 countsByYear W20053663672017 @default.
• W2005366367 countsByYear W20053663672018 @default.
• W2005366367 countsByYear W20053663672019 @default.
• W2005366367 countsByYear W20053663672021 @default.
• W2005366367 countsByYear W20053663672023 @default.
• W2005366367 crossrefType "journal-article" @default.
• W2005366367 hasAuthorship W2005366367A5004063791 @default.
• W2005366367 hasAuthorship W2005366367A5051109631 @default.
• W2005366367 hasAuthorship W2005366367A5059191212 @default.
• W2005366367 hasAuthorship W2005366367A5088687426 @default.
• W2005366367 hasConcept C126322002 @default.
• W2005366367 hasConcept C134018914 @default.
• W2005366367 hasConcept C150903083 @default.
• W2005366367 hasConcept C153911025 @default.
• W2005366367 hasConcept C167392928 @default.
• W2005366367 hasConcept C181199279 @default.
• W2005366367 hasConcept C185592680 @default.
• W2005366367 hasConcept C202751555 @default.
• W2005366367 hasConcept C203014093 @default.
• W2005366367 hasConcept C207001950 @default.
• W2005366367 hasConcept C2778163477 @default.
• W2005366367 hasConcept C2778394429 @default.
• W2005366367 hasConcept C2779281246 @default.
• W2005366367 hasConcept C2779980429 @default.
• W2005366367 hasConcept C2780644872 @default.
• W2005366367 hasConcept C2780942790 @default.
• W2005366367 hasConcept C55493867 @default.
• W2005366367 hasConcept C71924100 @default.
• W2005366367 hasConcept C86803240 @default.
• W2005366367 hasConcept C98274493 @default.
• W2005366367 hasConceptScore W2005366367C126322002 @default.
• W2005366367 hasConceptScore W2005366367C134018914 @default.
• W2005366367 hasConceptScore W2005366367C150903083 @default.
• W2005366367 hasConceptScore W2005366367C153911025 @default.
• W2005366367 hasConceptScore W2005366367C167392928 @default.
• W2005366367 hasConceptScore W2005366367C181199279 @default.
• W2005366367 hasConceptScore W2005366367C185592680 @default.
• W2005366367 hasConceptScore W2005366367C202751555 @default.
• W2005366367 hasConceptScore W2005366367C203014093 @default.
• W2005366367 hasConceptScore W2005366367C207001950 @default.
• W2005366367 hasConceptScore W2005366367C2778163477 @default.
• W2005366367 hasConceptScore W2005366367C2778394429 @default.
• W2005366367 hasConceptScore W2005366367C2779281246 @default.
• W2005366367 hasConceptScore W2005366367C2779980429 @default.
• W2005366367 hasConceptScore W2005366367C2780644872 @default.
• W2005366367 hasConceptScore W2005366367C2780942790 @default.
• W2005366367 hasConceptScore W2005366367C55493867 @default.
• W2005366367 hasConceptScore W2005366367C71924100 @default.
• W2005366367 hasConceptScore W2005366367C86803240 @default.
• W2005366367 hasConceptScore W2005366367C98274493 @default.
• W2005366367 hasIssue "5" @default.
• W2005366367 hasLocation W20053663671 @default.
• W2005366367 hasLocation W20053663672 @default.
• W2005366367 hasOpenAccess W2005366367 @default.
• W2005366367 hasPrimaryLocation W20053663671 @default.

• next