FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005366962> ?p ?o ?g. }

• W2005366962 endingPage "112" @default.
• W2005366962 startingPage "104" @default.
• W2005366962 abstract "α-Internexin is a type IV intermediate filament protein that is expressed abundantly in neurons during development of the peripheral and central nervous systems as well as in few neurons of the adult central nervous system. It has been suggested that α-internexin may act as a scaffold for the formation of neuronal intermediate filaments during early development. In addition, recent reports suggest that α-internexin could play a major role in two degenerative neurological disorders. We report here an analysis of mice with a targeted disruption of α-internexin gene. Unexpectedly, α-internexin −/− mice developed normally and did not exhibit overt phenotypes. Moreover, the absence of α-internexin did not interfere with neurite extension of cultured DRG neurons. The number and caliber of L4 ventral root axons remained unchanged in α-internexin −/− mice. In the retina, α-internexin begins to be expressed in retinal ganglion cells when their first axons reach the optic chiasma. Using HRP tracer, we show that the projection pattern of the RGC axons is not modified by the absence of α-internexin. Electron microscopy did not reveal significant differences in axonal calibers, in myelination of axons and in neurofilament structures between α-internexin −/− and control mice during development and at adult stage. These data indicate that α-internexin is not required for the polymerization of neurofilament in vivo. Mice deficient for both α-internexin and neurofilament light chain (NF-L) exhibited no over phenotypes as well. No intermediate filament structures were detectable in optic nerve of α-internexin −/−; NF-L −/− mice. Ours results do not support the hypothesis of a role for type IV intermediate filaments in axonal outgrowth during development of nervous system." @default.
• W2005366962 created "2016-06-24" @default.
• W2005366962 creator A5014379742 @default.
• W2005366962 creator A5038171886 @default.
• W2005366962 creator A5091664460 @default.
• W2005366962 date "1999-05-01" @default.
• W2005366962 modified "2023-09-26" @default.
• W2005366962 title "No requirement of α-internexin for nervous system development and for radial growth of axons" @default.
• W2005366962 cites W1551925364 @default.
• W2005366962 cites W1560947670 @default.
• W2005366962 cites W1814239271 @default.
• W2005366962 cites W1975103777 @default.
• W2005366962 cites W1976355798 @default.
• W2005366962 cites W1986234504 @default.
• W2005366962 cites W1988866780 @default.
• W2005366962 cites W2001115601 @default.
• W2005366962 cites W2011575330 @default.
• W2005366962 cites W2011980081 @default.
• W2005366962 cites W2013473672 @default.
• W2005366962 cites W2023659063 @default.
• W2005366962 cites W2029487653 @default.
• W2005366962 cites W2035412712 @default.
• W2005366962 cites W2035624754 @default.
• W2005366962 cites W2036377561 @default.
• W2005366962 cites W2051677048 @default.
• W2005366962 cites W2069448493 @default.
• W2005366962 cites W2071434138 @default.
• W2005366962 cites W2073614451 @default.
• W2005366962 cites W2073816113 @default.
• W2005366962 cites W2080328958 @default.
• W2005366962 cites W2087687043 @default.
• W2005366962 cites W2090095487 @default.
• W2005366962 cites W2099242521 @default.
• W2005366962 cites W2127892233 @default.
• W2005366962 cites W2137672131 @default.
• W2005366962 cites W2437876786 @default.
• W2005366962 cites W298213654 @default.
• W2005366962 doi "https://doi.org/10.1016/s0169-328x(99)00104-7" @default.
• W2005366962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10350642" @default.
• W2005366962 hasPublicationYear "1999" @default.
• W2005366962 type Work @default.
• W2005366962 sameAs 2005366962 @default.
• W2005366962 citedByCount "57" @default.
• W2005366962 countsByYear W20053669622013 @default.
• W2005366962 countsByYear W20053669622014 @default.
• W2005366962 countsByYear W20053669622015 @default.
• W2005366962 countsByYear W20053669622016 @default.
• W2005366962 countsByYear W20053669622018 @default.
• W2005366962 countsByYear W20053669622019 @default.
• W2005366962 countsByYear W20053669622020 @default.
• W2005366962 countsByYear W20053669622021 @default.
• W2005366962 countsByYear W20053669622023 @default.
• W2005366962 crossrefType "journal-article" @default.
• W2005366962 hasAuthorship W2005366962A5014379742 @default.
• W2005366962 hasAuthorship W2005366962A5038171886 @default.
• W2005366962 hasAuthorship W2005366962A5091664460 @default.
• W2005366962 hasConcept C104317684 @default.
• W2005366962 hasConcept C105702510 @default.
• W2005366962 hasConcept C113246987 @default.
• W2005366962 hasConcept C142669718 @default.
• W2005366962 hasConcept C1491633281 @default.
• W2005366962 hasConcept C157207234 @default.
• W2005366962 hasConcept C169760540 @default.
• W2005366962 hasConcept C202751555 @default.
• W2005366962 hasConcept C203014093 @default.
• W2005366962 hasConcept C204232928 @default.
• W2005366962 hasConcept C2776281502 @default.
• W2005366962 hasConcept C2777093970 @default.
• W2005366962 hasConcept C2780837183 @default.
• W2005366962 hasConcept C28521208 @default.
• W2005366962 hasConcept C529278444 @default.
• W2005366962 hasConcept C54355233 @default.
• W2005366962 hasConcept C545314008 @default.
• W2005366962 hasConcept C545706735 @default.
• W2005366962 hasConcept C78383274 @default.
• W2005366962 hasConcept C86803240 @default.
• W2005366962 hasConcept C94487597 @default.
• W2005366962 hasConcept C95444343 @default.
• W2005366962 hasConceptScore W2005366962C104317684 @default.
• W2005366962 hasConceptScore W2005366962C105702510 @default.
• W2005366962 hasConceptScore W2005366962C113246987 @default.
• W2005366962 hasConceptScore W2005366962C142669718 @default.
• W2005366962 hasConceptScore W2005366962C1491633281 @default.
• W2005366962 hasConceptScore W2005366962C157207234 @default.
• W2005366962 hasConceptScore W2005366962C169760540 @default.
• W2005366962 hasConceptScore W2005366962C202751555 @default.
• W2005366962 hasConceptScore W2005366962C203014093 @default.
• W2005366962 hasConceptScore W2005366962C204232928 @default.
• W2005366962 hasConceptScore W2005366962C2776281502 @default.
• W2005366962 hasConceptScore W2005366962C2777093970 @default.
• W2005366962 hasConceptScore W2005366962C2780837183 @default.
• W2005366962 hasConceptScore W2005366962C28521208 @default.
• W2005366962 hasConceptScore W2005366962C529278444 @default.
• W2005366962 hasConceptScore W2005366962C54355233 @default.
• W2005366962 hasConceptScore W2005366962C545314008 @default.
• W2005366962 hasConceptScore W2005366962C545706735 @default.
• W2005366962 hasConceptScore W2005366962C78383274 @default.
• W2005366962 hasConceptScore W2005366962C86803240 @default.

• next