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- W2005371311 abstract "Experiments were performed with rat vas deferens to verify whether agmatine, an endogenous ligand for adrenoceptors and imidazoline receptors, can influence sympathetic neurotransmission, with respect to contractions induced by transmural nerve stimulation, contractions induced by exogenous noradrenaline, and overflow of endogenous noradrenaline. It was shown that agmatine (a) caused a dose-dependent potentiation of electrically induced twitches, up to about 70% in relation to controls, (b) shifted to the right the inhibitory concentration-response curves for clonidine on electrically induced twitches, indicating competitive antagonism at presynaptic α-adrenoceptors, with a pA2 value of 4.12 ± 0.10, (c) shifted to the right the concentration-response curves for noradrenaline-induced contractions, indicating competitive antagonism at postsynaptic α-adrenoceptors as well, with a pA2 value of 4.03 ± 0.10, and (d) caused a dose-dependent increase of KCl-induced overflow of noradrenaline, up to about 90% in relation to controls. It is concluded that agmatine has multiple effects on sympathetic neurotransmission in rat vas deferens." @default.
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- W2005371311 date "1996-07-01" @default.
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- W2005371311 title "Functional properties of agmatine in rat vas deferens" @default.
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- W2005371311 doi "https://doi.org/10.1016/0014-2999(96)00274-9" @default.
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