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- W2005372155 abstract "Introduction B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor important for the differentiation and function of several types of immune cells. Because skin serves as a physical barrier and acts as an immune sentinel, we investigated whether Blimp-1 is involved in epidermal immune function. Methods Mice carrying epidermal-specific deletion of Prdm1 , the gene encoding Blimp-1, in adult stage in an inducible manner were generated for this study. Results We first show that Blimp-1 expression is reduced in stimulated mouse keratinocytes. Epidermal-specific deletion of Prdm1 in adult mice caused spontaneously inflamed skin characterized by massive dermal infiltration of neutrophils/macrophages and development of chronic inflammation, leading to increased release of cytokines/chemokines, including G-CSF, and enhanced granulopoiesis in bone marrow. Deletion of Blimp-1 in the epidermis of adult mice also led to sensitized inflammatory reactions in a disease model of contact dermatitis. Systemic increases in G-CSF contributed to the inflammatory responses because neutralization of G-CSF or deletion of the G-CSF gene, Csf3 , corrected neutrophilia and partially ameliorated the inflamed skin in Prdm1 -deficient mice. Conclusion We show a novel function for Blimp-1 acting in repressing cytokine/chemokine genes in restraining steady-state epidermal immune reactions." @default.
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- W2005372155 date "2012-09-01" @default.
- W2005372155 modified "2023-10-05" @default.
- W2005372155 title "O027 Inducible deletion of Prdm1 in adult epidermis causes chronic skin inflammation in mice" @default.
- W2005372155 doi "https://doi.org/10.1016/j.cyto.2012.06.060" @default.
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