Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005375686> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2005375686 endingPage "476" @default.
- W2005375686 startingPage "474" @default.
- W2005375686 abstract "Animal models of cathepsin D (CD) deficiency are characterized by a progressive and relentless neurodegenerative phenotype similar to that observed in Neuronal Ceroid Lipofuscinoses (NCL), a group of pediatric neurodegenerative diseases known collectively as Batten Disease. We have shown recently that the targeted deletion of the pro-apoptotic molecule Bax prevents apoptotic markers but not neuron death and neurodegeneration induced by CD deficiency, which suggests that alterations in the macroautophagy-lysosomal degradation pathway can mediate neuron death in NCL/Batten Disease in the absence of apoptosis. Herein, we review CD deficiency in the broader context of NCL and offer potential mechanisms for neuron death and neurodegeneration induced by CD deficiency.Addendum to:Cathepsin D Deficiency Induces Persistent Neurodegeneration in the Absence of Bax-Dependent ApoptosisJ.J. Shacka, B.J. Klocke, C. Young, M. Shibata, J.W. Olney, Y. Uchiyama, P. Saftig and K.A. RothJ Neurosci 2007; 27:2081-90" @default.
- W2005375686 created "2016-06-24" @default.
- W2005375686 creator A5047226936 @default.
- W2005375686 creator A5067993987 @default.
- W2005375686 date "2007-09-20" @default.
- W2005375686 modified "2023-09-23" @default.
- W2005375686 title "Cathepsin D Deficiency and NCL/Batten Disease: There’s More to Death than Apoptosis" @default.
- W2005375686 doi "https://doi.org/10.4161/auto.4341" @default.
- W2005375686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17495518" @default.
- W2005375686 hasPublicationYear "2007" @default.
- W2005375686 type Work @default.
- W2005375686 sameAs 2005375686 @default.
- W2005375686 citedByCount "27" @default.
- W2005375686 countsByYear W20053756862012 @default.
- W2005375686 countsByYear W20053756862013 @default.
- W2005375686 countsByYear W20053756862014 @default.
- W2005375686 countsByYear W20053756862015 @default.
- W2005375686 countsByYear W20053756862016 @default.
- W2005375686 countsByYear W20053756862017 @default.
- W2005375686 countsByYear W20053756862018 @default.
- W2005375686 countsByYear W20053756862019 @default.
- W2005375686 countsByYear W20053756862020 @default.
- W2005375686 countsByYear W20053756862022 @default.
- W2005375686 crossrefType "journal-article" @default.
- W2005375686 hasAuthorship W2005375686A5047226936 @default.
- W2005375686 hasAuthorship W2005375686A5067993987 @default.
- W2005375686 hasConcept C104317684 @default.
- W2005375686 hasConcept C126322002 @default.
- W2005375686 hasConcept C151730666 @default.
- W2005375686 hasConcept C153911025 @default.
- W2005375686 hasConcept C167844969 @default.
- W2005375686 hasConcept C169760540 @default.
- W2005375686 hasConcept C173633252 @default.
- W2005375686 hasConcept C181199279 @default.
- W2005375686 hasConcept C190283241 @default.
- W2005375686 hasConcept C2776925932 @default.
- W2005375686 hasConcept C2778230176 @default.
- W2005375686 hasConcept C2778650512 @default.
- W2005375686 hasConcept C2779134260 @default.
- W2005375686 hasConcept C2779343474 @default.
- W2005375686 hasConcept C31573885 @default.
- W2005375686 hasConcept C54355233 @default.
- W2005375686 hasConcept C55493867 @default.
- W2005375686 hasConcept C71924100 @default.
- W2005375686 hasConcept C86803240 @default.
- W2005375686 hasConcept C95444343 @default.
- W2005375686 hasConceptScore W2005375686C104317684 @default.
- W2005375686 hasConceptScore W2005375686C126322002 @default.
- W2005375686 hasConceptScore W2005375686C151730666 @default.
- W2005375686 hasConceptScore W2005375686C153911025 @default.
- W2005375686 hasConceptScore W2005375686C167844969 @default.
- W2005375686 hasConceptScore W2005375686C169760540 @default.
- W2005375686 hasConceptScore W2005375686C173633252 @default.
- W2005375686 hasConceptScore W2005375686C181199279 @default.
- W2005375686 hasConceptScore W2005375686C190283241 @default.
- W2005375686 hasConceptScore W2005375686C2776925932 @default.
- W2005375686 hasConceptScore W2005375686C2778230176 @default.
- W2005375686 hasConceptScore W2005375686C2778650512 @default.
- W2005375686 hasConceptScore W2005375686C2779134260 @default.
- W2005375686 hasConceptScore W2005375686C2779343474 @default.
- W2005375686 hasConceptScore W2005375686C31573885 @default.
- W2005375686 hasConceptScore W2005375686C54355233 @default.
- W2005375686 hasConceptScore W2005375686C55493867 @default.
- W2005375686 hasConceptScore W2005375686C71924100 @default.
- W2005375686 hasConceptScore W2005375686C86803240 @default.
- W2005375686 hasConceptScore W2005375686C95444343 @default.
- W2005375686 hasIssue "5" @default.
- W2005375686 hasLocation W20053756861 @default.
- W2005375686 hasLocation W20053756862 @default.
- W2005375686 hasOpenAccess W2005375686 @default.
- W2005375686 hasPrimaryLocation W20053756861 @default.
- W2005375686 hasRelatedWork W1908261543 @default.
- W2005375686 hasRelatedWork W2005375686 @default.
- W2005375686 hasRelatedWork W2024869398 @default.
- W2005375686 hasRelatedWork W2040107841 @default.
- W2005375686 hasRelatedWork W2076825051 @default.
- W2005375686 hasRelatedWork W2103377481 @default.
- W2005375686 hasRelatedWork W2159761135 @default.
- W2005375686 hasRelatedWork W4229004730 @default.
- W2005375686 hasRelatedWork W99101038 @default.
- W2005375686 hasRelatedWork W2563621124 @default.
- W2005375686 hasVolume "3" @default.
- W2005375686 isParatext "false" @default.
- W2005375686 isRetracted "false" @default.
- W2005375686 magId "2005375686" @default.
- W2005375686 workType "article" @default.