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- W2005376510 abstract "Photodynamic Therapy (PDT) is becoming a popular treatment modality for many superficial cancers and several non-malignant diseases. The use of PDT to treat solid tumors has been limited because there is currently is no clinically acceptable method of either characterizing the optical parameters of a target tissue or of determining dose delivered to the target tissue volume as delivered by a fibreoptic terminated in a cylindrical diffusing tip. Accurate light dosimetry methods, such as the Monte Carlo method, are of limited clinical utility. In this paper we describe the use of the P3-Approximation to optically characterize a light scattering and absorbing medium. Tissue characterization calculations made using the P3-Approximation are analytical and may be performed much faster than with numerical modeling. The process time needed to estimate the dose distribution is sufficiently short to permit iterative adjustment of the light source distribution to account for tissue inhomogeneities, in real time. P3-Approximation based optical dosimetry should be sufficiently fast to be incorporated into an iterative feedback control algorithm for the distribution of light across an interstitial source array. With the optical coefficients furnished by the P3-Approximation, the light dose delivered to the medium from a cylindrical fibreoptic source can be accurately calculated using a novel formulation of Diffusion Theory. The cylindrical fibreoptic diffuser is modeled as a Huygen's array: a finite yet continuous array of isotropic point sources. The predicted light fluence distribution from the Huygen's array compares favorably with experimental fluence measurements.© (2002) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only." @default.
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- W2005376510 date "2002-06-06" @default.
- W2005376510 modified "2023-09-23" @default.
- W2005376510 title "<title>Predicting fluence measurements from a cylindrical diffusing tip using the P3-approximation</title>" @default.
- W2005376510 doi "https://doi.org/10.1117/12.469350" @default.
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