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• W2005378082 endingPage "31376" @default.
• W2005378082 startingPage "31369" @default.
• W2005378082 abstract "The carcinoembryonic antigen (CEA) gene family encodes a large family of glycoproteins. Some are probably involved in the homeostasis/development of epithelial cells and granulocyte activation, while others e.g. the pregnancy-specific glycoproteins, are expressed in the placenta and are essential for a positive outcome of pregnancy. In this paper, we have characterized <i>cea5</i>, a member of the murine CEA gene family. RNase protection and <i>in situ</i> hybridization analyses revealed that Cea5 mRNA is exclusively synthesized in primary and secondary trophoblast giant cells of the placenta only during early stages of development. Full-length Cea5 cDNA was obtained by a reverse transcription-polymerase chain reaction using day 10.5 post-coitum placental RNA. The 1.6-kilobase pair (kb) Cea5 mRNA encodes a secreted glycoprotein with a predicted size of 30 kDa. It is composed of a leader peptide (L), one immunoglobulin (Ig) variable or N, and one Ig constant-like or A domain. This domain organization is unique within the human and murine CEA families. Two overlapping cosmid clones covering 54 kb of the <i>cea5</i> gene locus were mapped.<i>cea5</i> consists of three exons (L, N, A/3′-untranslated region exon) located within a 4-kb region. <i>rnCGM2</i>, the rat<i>cea5</i> counterpart, exhibits the same restricted expression pattern. This together with their exceptional conservation within the rat and murine CEA families and their absence from the human CEA family suggests that <i>cea5</i> and <i>rnCGM2</i> are of functional importance for rodent placental development." @default.
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• W2005378082 date "1997-12-01" @default.
• W2005378082 modified "2023-10-14" @default.
• W2005378082 title "cea5, a Structurally Divergent Member of the Murine Carcinoembryonic Antigen Gene Family, Is Exclusively Expressed during Early Placental Development in Trophoblast Giant Cells" @default.
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• W2005378082 doi "https://doi.org/10.1074/jbc.272.50.31369" @default.
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