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- W2005379311 abstract "A clinical phase II trial of postinfectional idiotype vaccination was performed in early stage HIV+ volunteers. The mAb 13B8.2 is directed against the CDR3-homologous CD4/D1 region implicated in HIV-gp120 binding. We have previously shown that this mAb induces HIV-gp120 cross-reactive immunity. In addition, the mAb 13B8.2 was well tolerated in a clinical phase-Ia trial. In this phase-II trial, 158 patients with 350–500 CD4+ cells/μl blood were randomised to receive either 1.2 mg of alum-precipitated mAb 13B8.2 or placebo. The mAb was well tolerated evoking predominantly local side effects. Multivariant analysis of clinical study endpoints demonstrated a significant response in the verum group (intend-to-treat analysis). Titres of HIV-1 neutralisation in vitro were raised along with HIV/gp120 antigen binding titres. Our data indicate that patients treated with the idiotype vaccine will produce an augmented specific anti-viral immune response. The vaccine might thus have a positive impact on the course of HIV disease." @default.
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- W2005379311 date "1989-01-01" @default.
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- W2005379311 title "Molecular analysis of receptor binding and infectivity of the human immunodeficiency virus" @default.
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- W2005379311 doi "https://doi.org/10.1016/s0923-2516(89)80124-4" @default.
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