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• W2005386937 abstract "ABSTRACT Treatment of infections caused by Staphylococcus aureus is often confounded by the bacterium's ability to develop resistance to chemotherapeutic agents. Methicillin-resistant S. aureus (MRSA) arises through the acquisition of staphylococcal chromosomal cassette mec (SCC mec ), a genomic island containing the methicillin resistance determinant, mecA . In contrast, resistance to vancomycin can result from exposure to the drug, a mechanism that is not dependent upon a gene acquisition event. Here we describe three MRSA strains that became resistant to vancomycin during passage in the presence of increasing concentrations of the drug. In each case two derivative strains were isolated, one that had lost mecA and one that retained mecA during passage. Strain 5836VR lost mecA by the site-specific chromosomal excision of SCC mec , while the other two strains (strains 3130VR and VP32) deleted portions of their SCC mec elements in a manner that appeared to involve IS 431 . Conversion to vancomycin resistance caused a decrease in the growth rate that was partially compensated for by the deletion of mecA . In mixed-culture competition experiments, vancomycin-resistant strains that lacked mecA readily outcompeted their mecA -containing counterparts, suggesting that the loss of mecA during conversion to vancomycin resistance was advantageous to the organism." @default.
• W2005386937 created "2016-06-24" @default.
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• W2005386937 date "2008-04-01" @default.
• W2005386937 modified "2023-09-27" @default.
• W2005386937 title "Spontaneous Deletion of the Methicillin Resistance Determinant, <i>mecA</i> , Partially Compensates for the Fitness Cost Associated with High-Level Vancomycin Resistance in <i>Staphylococcus aureus</i>" @default.
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• W2005386937 doi "https://doi.org/10.1128/aac.01164-07" @default.
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