FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005387789> ?p ?o ?g. }

• W2005387789 endingPage "90" @default.
• W2005387789 startingPage "80" @default.
• W2005387789 abstract "G-protein subunit Galphai2-deficient mice spontaneously develop an inflammatory bowel disease that clinically and histopathologically resembles ulcerative colitis in humans. The aim of this study was to determine whether immunological changes precede the development of colitis in Galphai2-deficient mice. Therefore, Galphai2-deficient mice with no clinical or histopathological signs of colitis were compared with Galphai2-deficient mice with established colitis and wild-type animals, concerning immunological parameters. Healthy Galphai2-deficient mice displayed an increased frequency of CD4+ T cells and a decreased frequency of CD19+ B lymphocytes in the intestinal mucosa compared with control mice. The CD4+ population was characterized by a memory phenotype, i.e. increased expression of CD44 and decreased expression of CD45RB and CD62L, as well as increased expression of the mucosal homing receptors integrins alpha4beta7 and alphaEbeta7. Production of pro-inflammatory cytokines, interleukin (IL)-1beta and interferon (IFN)-gamma, were increased in Galphai2-deficient mice before clinical signs of disease were evident. In addition, total immunoglobulin (Ig)G and IgA levels in large intestinal secretions were increased significantly compared with wild-type mice, and antibodies specific for the normal intestinal flora in large intestinal secretions were present in Galphai2-deficient mice several weeks before the onset of colitis. In contrast, antibodies against tropomyosin, a putative autoantigen in human ulcerative colitis, were not found in Galphai2-deficient mice before the onset of colitis, although they were present in animals with established disease. In conclusion, activation of the intestinal immune system precedes histopathological and clinical signs of inflammation in Galphai2-deficient mice, suggesting that immune abnormalities play an important role in the induction of colitis." @default.
• W2005387789 created "2016-06-24" @default.
• W2005387789 creator A5014938105 @default.
• W2005387789 creator A5028337034 @default.
• W2005387789 creator A5064918784 @default.
• W2005387789 creator A5076440132 @default.
• W2005387789 creator A5090941095 @default.
• W2005387789 date "2000-07-01" @default.
• W2005387789 modified "2023-10-14" @default.
• W2005387789 title "Immune Activation in the Intestinal Mucosa Before the Onset of Colitis in Galphai2-Deficient Mice" @default.
• W2005387789 cites W13941495 @default.
• W2005387789 cites W1535586386 @default.
• W2005387789 cites W1619160309 @default.
• W2005387789 cites W1727711006 @default.
• W2005387789 cites W1874013760 @default.
• W2005387789 cites W1887031720 @default.
• W2005387789 cites W1963809310 @default.
• W2005387789 cites W1965889113 @default.
• W2005387789 cites W1968508772 @default.
• W2005387789 cites W1970435627 @default.
• W2005387789 cites W1981416199 @default.
• W2005387789 cites W1981493299 @default.
• W2005387789 cites W1983552305 @default.
• W2005387789 cites W1983826199 @default.
• W2005387789 cites W1985323653 @default.
• W2005387789 cites W1991340166 @default.
• W2005387789 cites W2000208875 @default.
• W2005387789 cites W2005389617 @default.
• W2005387789 cites W2012066742 @default.
• W2005387789 cites W2012528572 @default.
• W2005387789 cites W2014257728 @default.
• W2005387789 cites W2014439319 @default.
• W2005387789 cites W2036500213 @default.
• W2005387789 cites W2042387365 @default.
• W2005387789 cites W2048875929 @default.
• W2005387789 cites W2052330087 @default.
• W2005387789 cites W2057003430 @default.
• W2005387789 cites W2058688958 @default.
• W2005387789 cites W2059675287 @default.
• W2005387789 cites W2066068867 @default.
• W2005387789 cites W2079096428 @default.
• W2005387789 cites W2080801828 @default.
• W2005387789 cites W2082078315 @default.
• W2005387789 cites W2085875957 @default.
• W2005387789 cites W2090631845 @default.
• W2005387789 cites W2095862769 @default.
• W2005387789 cites W2113855055 @default.
• W2005387789 cites W2137109050 @default.
• W2005387789 cites W2143157380 @default.
• W2005387789 cites W2325999030 @default.
• W2005387789 doi "https://doi.org/10.1046/j.1365-3083.2000.00759.x" @default.
• W2005387789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10886787" @default.
• W2005387789 hasPublicationYear "2000" @default.
• W2005387789 type Work @default.
• W2005387789 sameAs 2005387789 @default.
• W2005387789 citedByCount "53" @default.
• W2005387789 countsByYear W20053877892012 @default.
• W2005387789 countsByYear W20053877892013 @default.
• W2005387789 countsByYear W20053877892016 @default.
• W2005387789 countsByYear W20053877892017 @default.
• W2005387789 crossrefType "journal-article" @default.
• W2005387789 hasAuthorship W2005387789A5014938105 @default.
• W2005387789 hasAuthorship W2005387789A5028337034 @default.
• W2005387789 hasAuthorship W2005387789A5064918784 @default.
• W2005387789 hasAuthorship W2005387789A5076440132 @default.
• W2005387789 hasAuthorship W2005387789A5090941095 @default.
• W2005387789 hasConcept C126322002 @default.
• W2005387789 hasConcept C159654299 @default.
• W2005387789 hasConcept C203014093 @default.
• W2005387789 hasConcept C2775862500 @default.
• W2005387789 hasConcept C2776914184 @default.
• W2005387789 hasConcept C2778260677 @default.
• W2005387789 hasConcept C2779134260 @default.
• W2005387789 hasConcept C2780479503 @default.
• W2005387789 hasConcept C2908647359 @default.
• W2005387789 hasConcept C3019368612 @default.
• W2005387789 hasConcept C71924100 @default.
• W2005387789 hasConcept C86803240 @default.
• W2005387789 hasConcept C8891405 @default.
• W2005387789 hasConcept C99454951 @default.
• W2005387789 hasConceptScore W2005387789C126322002 @default.
• W2005387789 hasConceptScore W2005387789C159654299 @default.
• W2005387789 hasConceptScore W2005387789C203014093 @default.
• W2005387789 hasConceptScore W2005387789C2775862500 @default.
• W2005387789 hasConceptScore W2005387789C2776914184 @default.
• W2005387789 hasConceptScore W2005387789C2778260677 @default.
• W2005387789 hasConceptScore W2005387789C2779134260 @default.
• W2005387789 hasConceptScore W2005387789C2780479503 @default.
• W2005387789 hasConceptScore W2005387789C2908647359 @default.
• W2005387789 hasConceptScore W2005387789C3019368612 @default.
• W2005387789 hasConceptScore W2005387789C71924100 @default.
• W2005387789 hasConceptScore W2005387789C86803240 @default.
• W2005387789 hasConceptScore W2005387789C8891405 @default.
• W2005387789 hasConceptScore W2005387789C99454951 @default.
• W2005387789 hasIssue "1" @default.
• W2005387789 hasLocation W20053877891 @default.
• W2005387789 hasLocation W20053877892 @default.
• W2005387789 hasOpenAccess W2005387789 @default.

• next