Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005388548> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2005388548 endingPage "353" @default.
- W2005388548 startingPage "343" @default.
- W2005388548 abstract "Summary We have transfected human melanoma cell line 518A2 with the cDNA encoding interleukin-2 (IL-2) or granulocyte-macrophage colony-stimulating factor (GM-CSF), and compared cytokine-producing clones for their ability to induce melanoma-specific cytotoxic T lymphocytes (CTL) from autologous peripheral blood mononuclear cells (PBMC) in vitro. The parental cell line expressed HLA-A1, HLA-A2, ICAM-1, LFA-3, in addition to the common CTL antigens MAGE-1, MAGE-3, tyrosinase, gp100, and Melan-A/MART-1. Stimulation of autologous PBMC responders with the IL-2-transfected clone 518/IL2.14 specifically induced CTL lines reactive with all cell lines derived from the autologous patient. Strikingly, GM-CSF-transfected 518A2 cells did not induce anti-tumor CTL reactivity. CTL induction against 518/IL2.14 was independent of HLA class II expression or CD4 help. The parental cell line 518A2 gained immunogenic properties when high concentrations of IL-2 were supplied exogenously, indicating that IL-2 produced and present at high levels locally by itself enhanced immunogenicity. From the autologous CTL line reactive with 518/IL2.14, clones were generated against an as yet unknown antigen, which was present in all autologous melanoma cell lines as well as in 7 of 15 HLA-A2+ melanoma cell lines tested, but not in melanocytes. These results will be discussed with respect to the possibility of using IL-2-transfected melanoma cells as a vaccine for treatment of patients with melanoma." @default.
- W2005388548 created "2016-06-24" @default.
- W2005388548 creator A5026039423 @default.
- W2005388548 creator A5029547346 @default.
- W2005388548 creator A5037927878 @default.
- W2005388548 creator A5043865752 @default.
- W2005388548 creator A5057640133 @default.
- W2005388548 creator A5087182123 @default.
- W2005388548 creator A5091786437 @default.
- W2005388548 date "1997-09-01" @default.
- W2005388548 modified "2023-10-11" @default.
- W2005388548 title "Transfection of IL-2 Augments CTL Response to Human Melanoma Cells In Vitro" @default.
- W2005388548 doi "https://doi.org/10.1097/00002371-199709000-00003" @default.
- W2005388548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9336741" @default.
- W2005388548 hasPublicationYear "1997" @default.
- W2005388548 type Work @default.
- W2005388548 sameAs 2005388548 @default.
- W2005388548 citedByCount "15" @default.
- W2005388548 crossrefType "journal-article" @default.
- W2005388548 hasAuthorship W2005388548A5026039423 @default.
- W2005388548 hasAuthorship W2005388548A5029547346 @default.
- W2005388548 hasAuthorship W2005388548A5037927878 @default.
- W2005388548 hasAuthorship W2005388548A5043865752 @default.
- W2005388548 hasAuthorship W2005388548A5057640133 @default.
- W2005388548 hasAuthorship W2005388548A5087182123 @default.
- W2005388548 hasAuthorship W2005388548A5091786437 @default.
- W2005388548 hasConcept C137061746 @default.
- W2005388548 hasConcept C147483822 @default.
- W2005388548 hasConcept C147969180 @default.
- W2005388548 hasConcept C154317977 @default.
- W2005388548 hasConcept C167672396 @default.
- W2005388548 hasConcept C202751555 @default.
- W2005388548 hasConcept C203014093 @default.
- W2005388548 hasConcept C2777478134 @default.
- W2005388548 hasConcept C2777658100 @default.
- W2005388548 hasConcept C2777701055 @default.
- W2005388548 hasConcept C2778690821 @default.
- W2005388548 hasConcept C2780868878 @default.
- W2005388548 hasConcept C502942594 @default.
- W2005388548 hasConcept C54009773 @default.
- W2005388548 hasConcept C54355233 @default.
- W2005388548 hasConcept C552990157 @default.
- W2005388548 hasConcept C55493867 @default.
- W2005388548 hasConcept C71924100 @default.
- W2005388548 hasConcept C81089528 @default.
- W2005388548 hasConcept C81885089 @default.
- W2005388548 hasConcept C86803240 @default.
- W2005388548 hasConcept C8891405 @default.
- W2005388548 hasConceptScore W2005388548C137061746 @default.
- W2005388548 hasConceptScore W2005388548C147483822 @default.
- W2005388548 hasConceptScore W2005388548C147969180 @default.
- W2005388548 hasConceptScore W2005388548C154317977 @default.
- W2005388548 hasConceptScore W2005388548C167672396 @default.
- W2005388548 hasConceptScore W2005388548C202751555 @default.
- W2005388548 hasConceptScore W2005388548C203014093 @default.
- W2005388548 hasConceptScore W2005388548C2777478134 @default.
- W2005388548 hasConceptScore W2005388548C2777658100 @default.
- W2005388548 hasConceptScore W2005388548C2777701055 @default.
- W2005388548 hasConceptScore W2005388548C2778690821 @default.
- W2005388548 hasConceptScore W2005388548C2780868878 @default.
- W2005388548 hasConceptScore W2005388548C502942594 @default.
- W2005388548 hasConceptScore W2005388548C54009773 @default.
- W2005388548 hasConceptScore W2005388548C54355233 @default.
- W2005388548 hasConceptScore W2005388548C552990157 @default.
- W2005388548 hasConceptScore W2005388548C55493867 @default.
- W2005388548 hasConceptScore W2005388548C71924100 @default.
- W2005388548 hasConceptScore W2005388548C81089528 @default.
- W2005388548 hasConceptScore W2005388548C81885089 @default.
- W2005388548 hasConceptScore W2005388548C86803240 @default.
- W2005388548 hasConceptScore W2005388548C8891405 @default.
- W2005388548 hasIssue "5" @default.
- W2005388548 hasLocation W20053885481 @default.
- W2005388548 hasLocation W20053885482 @default.
- W2005388548 hasOpenAccess W2005388548 @default.
- W2005388548 hasPrimaryLocation W20053885481 @default.
- W2005388548 hasRelatedWork W1510522147 @default.
- W2005388548 hasRelatedWork W1549922507 @default.
- W2005388548 hasRelatedWork W1605884721 @default.
- W2005388548 hasRelatedWork W1985728487 @default.
- W2005388548 hasRelatedWork W1999535057 @default.
- W2005388548 hasRelatedWork W2010169347 @default.
- W2005388548 hasRelatedWork W2027917976 @default.
- W2005388548 hasRelatedWork W2102262438 @default.
- W2005388548 hasRelatedWork W2125092533 @default.
- W2005388548 hasRelatedWork W2469256847 @default.
- W2005388548 hasVolume "20" @default.
- W2005388548 isParatext "false" @default.
- W2005388548 isRetracted "false" @default.
- W2005388548 magId "2005388548" @default.
- W2005388548 workType "article" @default.