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- W2005391177 abstract "Chronic infection with hepatitis C virus (HCV) is one of the mostimportant causes of chronic liver disease, which can progress to cirrhosis andhepatocellular carcinoma (HCC). It is well established that advanced forms ofthe disease are accompanied by overt and global cognitive deficits (hepaticencephalopathy) but now there is a growing evidence that the alterations incerebral function in patients with chronic HCV infection may appear long beforethe development of severe liver cirrhosis, it has been hypothesized that it isrelated to a direct effect of HCV on the brain; or the neurotoxic effect ofHCV-related systemic inflammation. The purpose of the study was to assess thepossible existence of executive dysfunction in chronic HCV infected patients.One hundred elderly patients aged 60 years and above agreed to participate inthis study; 50 patients were HCV positive (cases) and 50 patients were HCVnegative (controls). All participants were subjected to the following:diagnosis of HCV by detection of HCV antibodies using ELISA technique,non-invasive assessment of liver condition, and evaluation of executivefunctions using 5 neuropsychological tests. The study showed that there was asignificant difference between cases and controls regarding 2 executivefunction tests related to the phonological loop component of working memoryamong HCV positive patients. The study concluded that chronic HCV infection isaccompanied by dysexecutive performance." @default.
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- W2005391177 date "2014-01-01" @default.
- W2005391177 modified "2023-10-01" @default.
- W2005391177 title "Dysexecutive Performance of Elderly Patients with Chronic Hepatitis C Virus Infection" @default.
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- W2005391177 doi "https://doi.org/10.4236/aar.2014.34037" @default.
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