FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005394703> ?p ?o ?g. }

• W2005394703 endingPage "510" @default.
• W2005394703 startingPage "499" @default.
• W2005394703 abstract "BACKGROUND: Cold hemagglutinins are generally immunoglobulin M (IgM) κ antibodies reactive at temperatures below 37°C and if of high titer may cause hemolysis. Platelet (PLT) cold agglutinins (CAs) are rare and poorly characterized. A detailed molecular characterization of the variable domains of a pathologic, PLT‐reactive, CA is presented. CASE REPORT: A 70‐year‐old woman was admitted with rectal bleeding accompanied by widespread petechiae, bruising, tongue and buccal mucosa bleeding, and epistaxes and proved refractory to HLA‐ and HPA‐matched PLTs. Detailed investigation showed monoclonal heavy‐chain gene rearrangement with an IgM paraprotein of 3.3 g per L and a trace of κ Bence Jones protein in the urine, compatible with a diagnosis of secretory B‐cell non‐Hodgkin's lymphoma (B‐NHL). PLT antibody (PAIg) investigations revealed a potent IgM κ PLT CA. Sequencing of the rearranged variable domain genes of the malignant clone together with idiotype‐specific antibodies obtained by DNA‐based immunization of rabbits and matrix‐assisted laser desorption/ionization–time‐of‐flight analysis of the PAIgM provided a irrefutable link between the thrombocytopenia, the IgM paraprotein, and the PAIgM against αIIbβ3. The thrombocytopenia and bleeding were refractory to standard treatment and PLT transfusion, but treatment with rituximab resulted in a recovery of the PLT count and a complete remission of B‐NHL. CONCLUSION: The IgM κ paraprotein derived from the malignant B‐cell clone was a potent and clinically significant CA against αIIbβ3. The testing for PLT CAs in patients with a paraprotein and refractory to matched PLTs may aid the selection of appropriate treatment." @default.
• W2005394703 created "2016-06-24" @default.
• W2005394703 creator A5008471606 @default.
• W2005394703 creator A5014699562 @default.
• W2005394703 creator A5026724408 @default.
• W2005394703 creator A5041477966 @default.
• W2005394703 creator A5046418554 @default.
• W2005394703 creator A5057036316 @default.
• W2005394703 creator A5082445979 @default.
• W2005394703 creator A5088962154 @default.
• W2005394703 creator A5089769089 @default.
• W2005394703 date "2007-02-21" @default.
• W2005394703 modified "2023-10-15" @default.
• W2005394703 title "Molecular characterization of the variable domains of an ?IIb?3-specific immunoglobulin�M ? platelet cold agglutinin in a follicular lymphoma patient with treatment refractory autoimmune thrombocytopenia: idiotypic overlap between ?IIb?3 integrin antibodies" @default.
• W2005394703 cites W129781713 @default.
• W2005394703 cites W1534015687 @default.
• W2005394703 cites W1549258100 @default.
• W2005394703 cites W1567813092 @default.
• W2005394703 cites W1826524642 @default.
• W2005394703 cites W1938388466 @default.
• W2005394703 cites W1963866821 @default.
• W2005394703 cites W1964273640 @default.
• W2005394703 cites W1996352022 @default.
• W2005394703 cites W1997870358 @default.
• W2005394703 cites W2001101301 @default.
• W2005394703 cites W2008109029 @default.
• W2005394703 cites W2015884421 @default.
• W2005394703 cites W2017529374 @default.
• W2005394703 cites W2021385126 @default.
• W2005394703 cites W2024345628 @default.
• W2005394703 cites W2031530229 @default.
• W2005394703 cites W2036484716 @default.
• W2005394703 cites W2042129159 @default.
• W2005394703 cites W2046279209 @default.
• W2005394703 cites W2048104300 @default.
• W2005394703 cites W2050727651 @default.
• W2005394703 cites W2051430573 @default.
• W2005394703 cites W2052726117 @default.
• W2005394703 cites W2067331360 @default.
• W2005394703 cites W2067836657 @default.
• W2005394703 cites W2068750735 @default.
• W2005394703 cites W2072695060 @default.
• W2005394703 cites W2073742126 @default.
• W2005394703 cites W2074560324 @default.
• W2005394703 cites W2080568927 @default.
• W2005394703 cites W2088100743 @default.
• W2005394703 cites W2093334559 @default.
• W2005394703 cites W2093826411 @default.
• W2005394703 cites W2096784084 @default.
• W2005394703 cites W2102664819 @default.
• W2005394703 cites W2116621437 @default.
• W2005394703 cites W2135818004 @default.
• W2005394703 cites W2150633410 @default.
• W2005394703 cites W2150822570 @default.
• W2005394703 cites W2153439039 @default.
• W2005394703 cites W2154786812 @default.
• W2005394703 cites W2154804875 @default.
• W2005394703 cites W219411466 @default.
• W2005394703 cites W2259989861 @default.
• W2005394703 cites W2317365282 @default.
• W2005394703 cites W2406447473 @default.
• W2005394703 cites W2411421886 @default.
• W2005394703 cites W2461339661 @default.
• W2005394703 cites W2469558758 @default.
• W2005394703 cites W4211228439 @default.
• W2005394703 doi "https://doi.org/10.1111/j.1537-2995.2006.01142.x" @default.
• W2005394703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17319832" @default.
• W2005394703 hasPublicationYear "2007" @default.
• W2005394703 type Work @default.
• W2005394703 sameAs 2005394703 @default.
• W2005394703 citedByCount "3" @default.
• W2005394703 countsByYear W20053947032014 @default.
• W2005394703 countsByYear W20053947032019 @default.
• W2005394703 crossrefType "journal-article" @default.
• W2005394703 hasAuthorship W2005394703A5008471606 @default.
• W2005394703 hasAuthorship W2005394703A5014699562 @default.
• W2005394703 hasAuthorship W2005394703A5026724408 @default.
• W2005394703 hasAuthorship W2005394703A5041477966 @default.
• W2005394703 hasAuthorship W2005394703A5046418554 @default.
• W2005394703 hasAuthorship W2005394703A5057036316 @default.
• W2005394703 hasAuthorship W2005394703A5082445979 @default.
• W2005394703 hasAuthorship W2005394703A5088962154 @default.
• W2005394703 hasAuthorship W2005394703A5089769089 @default.
• W2005394703 hasConcept C159654299 @default.
• W2005394703 hasConcept C203014093 @default.
• W2005394703 hasConcept C2780653079 @default.
• W2005394703 hasConcept C2910849039 @default.
• W2005394703 hasConcept C71924100 @default.
• W2005394703 hasConceptScore W2005394703C159654299 @default.
• W2005394703 hasConceptScore W2005394703C203014093 @default.
• W2005394703 hasConceptScore W2005394703C2780653079 @default.
• W2005394703 hasConceptScore W2005394703C2910849039 @default.
• W2005394703 hasConceptScore W2005394703C71924100 @default.
• W2005394703 hasIssue "3" @default.
• W2005394703 hasLocation W20053947031 @default.
• W2005394703 hasLocation W20053947032 @default.
• W2005394703 hasOpenAccess W2005394703 @default.
• W2005394703 hasPrimaryLocation W20053947031 @default.

• next