Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005397488> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2005397488 abstract "Few investigations on the pharmacokinetics of isolated lung perfusion (ILP) regional chemotherapy in tumors have been conducted. The purpose of this study was to evaluate the pharmacokinetic character of ILP in tumor tissues. Materials and Methods A solitary tumor nodule model was established in Fisher 344 rats by inoculating 1.0 x 10(6) methylcholanthrene-induced sarcoma cells into the left lung. On 14-21 days after the inoculation of tumor cells, rats were randomized into groups subjected to 10, 20, 40 or 60 min ILP with cis-diamminedichloroplatinum (CDDP) at concentrations of 25, 50, or 100 microg/ml. Total platinum concentration in tumors was measured by a flameless atomic absorption spectrophotometer.The average tumor weights and total platinum concentrations were not significantly different among the perfusion groups. We found, however, that the total platinum concentrations in tumor nodules were significantly correlated inversely with the tumor weight (total platinum concentration in tumor = 1.167 x 1/tumor wt; R(2) = 0.981; P < 0.001).The concentration of total platinum in the tumor tissue was found to be dependent on the weight of the tumor in ILP. Higher concentrations of total platinum were expressed in smaller tumor nodules than larger ones, indicating that ILP may be more effective against small tumors than large ones. Therefore, we suggest that large tumor legions should be debulked before ILP in patients with an unresectable lung tumor." @default.
- W2005397488 created "2016-06-24" @default.
- W2005397488 creator A5003932455 @default.
- W2005397488 creator A5015906614 @default.
- W2005397488 creator A5026891445 @default.
- W2005397488 creator A5032487888 @default.
- W2005397488 creator A5038064790 @default.
- W2005397488 date "2000-01-01" @default.
- W2005397488 modified "2023-09-27" @default.
- W2005397488 title "Relationship between the concentration of CDDP in tumor and tumor size after isolated lung perfusion treatment experimental study on a solitary pulmonary sarcoma model in rats" @default.
- W2005397488 cites W1970786602 @default.
- W2005397488 cites W1970880370 @default.
- W2005397488 cites W1981185663 @default.
- W2005397488 cites W1986065067 @default.
- W2005397488 cites W1992619795 @default.
- W2005397488 cites W1993933282 @default.
- W2005397488 cites W1999375990 @default.
- W2005397488 cites W2003643749 @default.
- W2005397488 cites W2017058200 @default.
- W2005397488 cites W2017897250 @default.
- W2005397488 cites W2048914158 @default.
- W2005397488 cites W2055018123 @default.
- W2005397488 cites W2072387750 @default.
- W2005397488 cites W2148797074 @default.
- W2005397488 cites W2160710205 @default.
- W2005397488 cites W2229046373 @default.
- W2005397488 cites W2263318751 @default.
- W2005397488 cites W2405064923 @default.
- W2005397488 cites W4249995064 @default.
- W2005397488 cites W4301497321 @default.
- W2005397488 doi "https://doi.org/10.1002/1096-9098(200011)75:3<193::aid-jso7>3.0.co;2-x" @default.
- W2005397488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11088051" @default.
- W2005397488 hasPublicationYear "2000" @default.
- W2005397488 type Work @default.
- W2005397488 sameAs 2005397488 @default.
- W2005397488 citedByCount "6" @default.
- W2005397488 countsByYear W20053974882016 @default.
- W2005397488 crossrefType "journal-article" @default.
- W2005397488 hasAuthorship W2005397488A5003932455 @default.
- W2005397488 hasAuthorship W2005397488A5015906614 @default.
- W2005397488 hasAuthorship W2005397488A5026891445 @default.
- W2005397488 hasAuthorship W2005397488A5032487888 @default.
- W2005397488 hasAuthorship W2005397488A5038064790 @default.
- W2005397488 hasConcept C112705442 @default.
- W2005397488 hasConcept C126322002 @default.
- W2005397488 hasConcept C142724271 @default.
- W2005397488 hasConcept C146957229 @default.
- W2005397488 hasConcept C2776694085 @default.
- W2005397488 hasConcept C2777714996 @default.
- W2005397488 hasConcept C2778256501 @default.
- W2005397488 hasConcept C71924100 @default.
- W2005397488 hasConceptScore W2005397488C112705442 @default.
- W2005397488 hasConceptScore W2005397488C126322002 @default.
- W2005397488 hasConceptScore W2005397488C142724271 @default.
- W2005397488 hasConceptScore W2005397488C146957229 @default.
- W2005397488 hasConceptScore W2005397488C2776694085 @default.
- W2005397488 hasConceptScore W2005397488C2777714996 @default.
- W2005397488 hasConceptScore W2005397488C2778256501 @default.
- W2005397488 hasConceptScore W2005397488C71924100 @default.
- W2005397488 hasLocation W20053974881 @default.
- W2005397488 hasLocation W20053974882 @default.
- W2005397488 hasOpenAccess W2005397488 @default.
- W2005397488 hasPrimaryLocation W20053974881 @default.
- W2005397488 hasRelatedWork W1494540281 @default.
- W2005397488 hasRelatedWork W1528970564 @default.
- W2005397488 hasRelatedWork W1899052062 @default.
- W2005397488 hasRelatedWork W1963939386 @default.
- W2005397488 hasRelatedWork W1969736249 @default.
- W2005397488 hasRelatedWork W1986065067 @default.
- W2005397488 hasRelatedWork W2012269420 @default.
- W2005397488 hasRelatedWork W2015873549 @default.
- W2005397488 hasRelatedWork W2017058200 @default.
- W2005397488 hasRelatedWork W2065985007 @default.
- W2005397488 hasRelatedWork W2069088421 @default.
- W2005397488 hasRelatedWork W2072403754 @default.
- W2005397488 hasRelatedWork W2075289700 @default.
- W2005397488 hasRelatedWork W2081487412 @default.
- W2005397488 hasRelatedWork W2089293263 @default.
- W2005397488 hasRelatedWork W2090855876 @default.
- W2005397488 hasRelatedWork W2120406858 @default.
- W2005397488 hasRelatedWork W2155660931 @default.
- W2005397488 hasRelatedWork W2290241957 @default.
- W2005397488 hasRelatedWork W2474061940 @default.
- W2005397488 isParatext "false" @default.
- W2005397488 isRetracted "false" @default.
- W2005397488 magId "2005397488" @default.
- W2005397488 workType "article" @default.