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• W2005402088 endingPage "1226" @default.
• W2005402088 startingPage "1217" @default.
• W2005402088 abstract "Chronic kidney disease (CKD) has become a worldwide public health problem. Renal transplantation is the treatment of choice for end-stage renal disease, but is limited by a small number of organ donors and the immune barrier. To overcome these problems, new therapeutic strategies for tissue repair have recently emerged.We discuss the therapeutic potential of mesenchymal stem cells (MSCs) in kidney injury and examine the latest reports providing evidence supporting MSC efficacy in the treatment of chronic renal failure (CRF).MSCs improve histological and functional outcomes in various CRF model systems. Paracrine effects rather than transdifferentiation might result in the prevention of progressive renal failure. In addition, MSCs can reprogram kidney cell differentiation, and modulate neo-kidney transplantation in CRF.Although many practical problems remain to be addressed, treatment with MSCs will enter the mainstream of CRF treatment." @default.
• W2005402088 created "2016-06-24" @default.
• W2005402088 creator A5000066237 @default.
• W2005402088 creator A5041023351 @default.
• W2005402088 creator A5059329731 @default.
• W2005402088 date "2010-07-13" @default.
• W2005402088 modified "2023-10-17" @default.
• W2005402088 title "Mesenchymal stem cell therapy for chronic renal failure" @default.
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