Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005403893> ?p ?o ?g. }
- W2005403893 abstract "Turing models have been proposed to explain the emergence of digits during limb development. However, so far the molecular components that would give rise to Turing patterns are elusive. We have recently shown that a particular type of receptor-ligand interaction can give rise to Schnakenberg-type Turing patterns, which reproduce patterning during lung and kidney branching morphogenesis. Recent knockout experiments have identified Smad4 as a key protein in digit patterning. We show here that the BMP-receptor interaction meets the conditions for a Schnakenberg-type Turing pattern and that the resulting model reproduces available wildtype and mutant data on the expression patterns of BMP, its receptor and Fgfs in the apical ectodermal ridge (AER) when solved on a realistic 2D domain that we extracted from limb bud images of E11.5 mouse embryos. We propose that receptor-ligand-based mechanisms serve as a molecular basis for the emergence of Turing patterns in many developing tissues." @default.
- W2005403893 created "2016-06-24" @default.
- W2005403893 creator A5000913635 @default.
- W2005403893 creator A5013308239 @default.
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- W2005403893 creator A5042617077 @default.
- W2005403893 creator A5075796863 @default.
- W2005403893 date "2012-12-18" @default.
- W2005403893 modified "2023-10-03" @default.
- W2005403893 title "Digit patterning during limb development as a result of the BMP-receptor interaction" @default.
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