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- W2005407629 abstract "Abstract Castration of male rats led to both increased biliary excretion of aldosterone metabolites and clearance of aldosterone radiometabolites from the plasma at rates similar to those of intact females and the elimination of the previously observed sex-dependence of these processes. Ovariectomy of female rats did not cause any effects in these processes. Treatment of both castrated male and ovariectomized female rats with testosterone reintroduced the sex-dependence so that the radiometabolites of aldosterone were cleared from the plasma and excreted via the bile of these animals at a slower rate typical of males. These findings suggest that the presence of androgens plays a major role in regulating the routes of hepatic metabolism of aldosterone, the subsequent rates of excretion of aldosterone metabolites via the bile and hence the concentration of aldosterone and the composition of the metabolites of aldosterone attained in the plasma during the latent period of the hormone. Hypophysectomy of femalerats significantly altered both the biliary excretion of aldosterone metabolites and the clearance from the plasma of aldosterone metabolites to rates typically observed in males. However, hypophysectomy of male rats did not cause changes in either of these two processes. These findings suggest that the presence of an intact pituitary is required for the sex-dependence of these processes in rats." @default.
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- W2005407629 date "1976-11-01" @default.
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- W2005407629 title "Regulation of plasma levels of aldosterone and its metabolites during the latent period of aldosterone" @default.
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- W2005407629 doi "https://doi.org/10.1016/0022-4731(76)90020-0" @default.
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