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- W2005409218 abstract "We report on a theoretical study showing that the leak conductance density, ${G}_{L}$, in the squid giant axon appears to be optimal for the action potential firing frequency. More precisely, the standard assumption that the leak current is composed of chloride ions leads to the result that the experimental value for ${G}_{L}$ is very close to the optimal value in the Hodgkin-Huxley model, which minimizes the absolute refractory period of the action potential, thereby maximizing the maximum firing frequency under stimulation by sharp, brief input current spikes to one end of the axon. The measured value of ${G}_{L}$ also appears to be close to optimal for the frequency of repetitive firing caused by a constant current input to one end of the axon, especially when temperature variations are taken into account. If, by contrast, the leak current is assumed to be composed of separate voltage-independent sodium and potassium currents, then these optimizations are not observed." @default.
- W2005409218 created "2016-06-24" @default.
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- W2005409218 date "2010-08-06" @default.
- W2005409218 modified "2023-10-11" @default.
- W2005409218 title "Optimization of the leak conductance in the squid giant axon" @default.
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- W2005409218 doi "https://doi.org/10.1103/physreve.82.021906" @default.
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