FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005417512> ?p ?o ?g. }

• W2005417512 endingPage "190" @default.
• W2005417512 startingPage "181" @default.
• W2005417512 abstract "Abstract Hyperfunctional endocrine thyroid and testicular disorders can frequently be traced back to gain-of-function mutations in glycoprotein hormone receptor genes. Deletion mutations in the third intracellular (i3) loop of the TSH receptor have recently been identified as a cause of constitutive receptor activity. To examine whether the underlying mechanism of receptor activation applies to all glycoprotein hormone receptors, we created deletion mutations in the LH and FSH receptors. In analogy to the situation with the TSH receptor, a deletion of nine amino acids resulted in constitutive activity irrespective of the location of deletions within the i3 loop of the LH receptor. In contrast, only one (Δ563–566) of four different 4-amino acid deletion mutants displayed agonist-independent activity. Systematic examination of the structural requirements for this effect in the Δ563–566 mutant revealed that only deletions including D564 resulted in constitutive receptor activity. Replacement of D564 by G, K, and N led to agonist-independent cAMP formation while introduction of a negatively charged E silenced constitutive receptor activity, indicating that an anionic amino acid at this position may be required to maintain an inactive receptor conformation. Insertion of A residues up- and downstream of D564 did not perturb receptor quiescence, showing that a certain degree of spatial freedom of the negatively charged amino acid within the context of the i3 loop is well tolerated. In contrast to the results obtained with the LH receptor, deletion of the corresponding D567 from the i3 loop of the FSH receptor did not cause constitutive receptor activation, highlighting significant differences in the activation mechanism of gonadotropin receptors." @default.
• W2005417512 created "2016-06-24" @default.
• W2005417512 creator A5002097111 @default.
• W2005417512 creator A5007617070 @default.
• W2005417512 creator A5035520172 @default.
• W2005417512 creator A5063460244 @default.
• W2005417512 creator A5065854689 @default.
• W2005417512 date "1999-02-01" @default.
• W2005417512 modified "2023-10-14" @default.
• W2005417512 title "Role of the Third Intracellular Loop for the Activation of Gonadotropin Receptors" @default.
• W2005417512 cites W1489775551 @default.
• W2005417512 cites W1491183049 @default.
• W2005417512 cites W1541533178 @default.
• W2005417512 cites W1590595627 @default.
• W2005417512 cites W1614960091 @default.
• W2005417512 cites W1677997440 @default.
• W2005417512 cites W1751435293 @default.
• W2005417512 cites W1977158207 @default.
• W2005417512 cites W1985937682 @default.
• W2005417512 cites W1998541756 @default.
• W2005417512 cites W2010309528 @default.
• W2005417512 cites W2012638283 @default.
• W2005417512 cites W2016770664 @default.
• W2005417512 cites W2026005641 @default.
• W2005417512 cites W2028700455 @default.
• W2005417512 cites W2043813981 @default.
• W2005417512 cites W2046826628 @default.
• W2005417512 cites W2049897189 @default.
• W2005417512 cites W2064552105 @default.
• W2005417512 cites W2071587854 @default.
• W2005417512 cites W2093094352 @default.
• W2005417512 cites W2122073716 @default.
• W2005417512 cites W2166316892 @default.
• W2005417512 cites W2238525991 @default.
• W2005417512 cites W2321550529 @default.
• W2005417512 cites W2339219645 @default.
• W2005417512 cites W263812101 @default.
• W2005417512 doi "https://doi.org/10.1210/mend.13.2.0233" @default.
• W2005417512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9973249" @default.
• W2005417512 hasPublicationYear "1999" @default.
• W2005417512 type Work @default.
• W2005417512 sameAs 2005417512 @default.
• W2005417512 citedByCount "56" @default.
• W2005417512 countsByYear W20054175122013 @default.
• W2005417512 countsByYear W20054175122014 @default.
• W2005417512 countsByYear W20054175122015 @default.
• W2005417512 countsByYear W20054175122016 @default.
• W2005417512 countsByYear W20054175122017 @default.
• W2005417512 countsByYear W20054175122018 @default.
• W2005417512 countsByYear W20054175122019 @default.
• W2005417512 countsByYear W20054175122020 @default.
• W2005417512 countsByYear W20054175122022 @default.
• W2005417512 crossrefType "journal-article" @default.
• W2005417512 hasAuthorship W2005417512A5002097111 @default.
• W2005417512 hasAuthorship W2005417512A5007617070 @default.
• W2005417512 hasAuthorship W2005417512A5035520172 @default.
• W2005417512 hasAuthorship W2005417512A5063460244 @default.
• W2005417512 hasAuthorship W2005417512A5065854689 @default.
• W2005417512 hasBestOaLocation W20054175121 @default.
• W2005417512 hasConcept C104317684 @default.
• W2005417512 hasConcept C116016267 @default.
• W2005417512 hasConcept C134018914 @default.
• W2005417512 hasConcept C170493617 @default.
• W2005417512 hasConcept C17971392 @default.
• W2005417512 hasConcept C2776652619 @default.
• W2005417512 hasConcept C2777608072 @default.
• W2005417512 hasConcept C2778575703 @default.
• W2005417512 hasConcept C2778938600 @default.
• W2005417512 hasConcept C2779279165 @default.
• W2005417512 hasConcept C29390026 @default.
• W2005417512 hasConcept C526584372 @default.
• W2005417512 hasConcept C55493867 @default.
• W2005417512 hasConcept C63932345 @default.
• W2005417512 hasConcept C71315377 @default.
• W2005417512 hasConcept C75184817 @default.
• W2005417512 hasConcept C86339819 @default.
• W2005417512 hasConcept C86803240 @default.
• W2005417512 hasConcept C91977512 @default.
• W2005417512 hasConceptScore W2005417512C104317684 @default.
• W2005417512 hasConceptScore W2005417512C116016267 @default.
• W2005417512 hasConceptScore W2005417512C134018914 @default.
• W2005417512 hasConceptScore W2005417512C170493617 @default.
• W2005417512 hasConceptScore W2005417512C17971392 @default.
• W2005417512 hasConceptScore W2005417512C2776652619 @default.
• W2005417512 hasConceptScore W2005417512C2777608072 @default.
• W2005417512 hasConceptScore W2005417512C2778575703 @default.
• W2005417512 hasConceptScore W2005417512C2778938600 @default.
• W2005417512 hasConceptScore W2005417512C2779279165 @default.
• W2005417512 hasConceptScore W2005417512C29390026 @default.
• W2005417512 hasConceptScore W2005417512C526584372 @default.
• W2005417512 hasConceptScore W2005417512C55493867 @default.
• W2005417512 hasConceptScore W2005417512C63932345 @default.
• W2005417512 hasConceptScore W2005417512C71315377 @default.
• W2005417512 hasConceptScore W2005417512C75184817 @default.
• W2005417512 hasConceptScore W2005417512C86339819 @default.
• W2005417512 hasConceptScore W2005417512C86803240 @default.
• W2005417512 hasConceptScore W2005417512C91977512 @default.
• W2005417512 hasIssue "2" @default.

• next