Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005419775> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2005419775 endingPage "275" @default.
- W2005419775 startingPage "270" @default.
- W2005419775 abstract "Background: Laryngeal cancer has one of the worst recurrence rates for any malignancy, is known to be influenced by several environmental factors, and it is significantly more common in males than females. Familial clusterings of laryngeal cancer have been reported but no systematic evaluation of the clinical feature of the disease or an in-depth analysis of familial forms of the disease has been made. In this study we wished to determine if there are any clinical features of the disease that may be useful for the identification of genetic susceptibility loci associated with the disorder. Methods: Seven hundred and fifty-three unselected consecutive laryngeal cancer patients were analyzed depending on sex, age, smoking behavior, and clinical features (localization, tumor size, lymph node metastases, grading, and staging) and the presence of cancer among first-degree relatives. The presence of at least a second relative affected by laryngeal cancer was considered to be a Familial Larynx Cancer (FLC) case (44 patients). Results: Women in the FLC group had larger tumors, higher proportion of lymph node metastases, higher grading, staging, and a tendency towards supraglottic localization than the sporadic larynx cancer cases. The aggressive pattern characterized by presence of metastases, tumor size >2, and grading = 3 revealed to be significantly associated with FLC (OR = 10.02, p = 0.0003). Conclusions: The study revealed a distinct clinical pattern of disease in familial cases of laryngeal cancer, which may provide a valuable basis for the identification of genetic determinants of this malignancy." @default.
- W2005419775 created "2016-06-24" @default.
- W2005419775 creator A5016817677 @default.
- W2005419775 creator A5017185687 @default.
- W2005419775 creator A5022175772 @default.
- W2005419775 creator A5023115923 @default.
- W2005419775 creator A5025449315 @default.
- W2005419775 creator A5039890157 @default.
- W2005419775 creator A5084478593 @default.
- W2005419775 creator A5068891623 @default.
- W2005419775 date "2007-01-01" @default.
- W2005419775 modified "2023-10-16" @default.
- W2005419775 title "Clinical and epidemiological features of familial laryngeal cancer in Poland" @default.
- W2005419775 cites W1594464537 @default.
- W2005419775 cites W1976060086 @default.
- W2005419775 cites W1978368810 @default.
- W2005419775 cites W1981017621 @default.
- W2005419775 cites W1990604199 @default.
- W2005419775 cites W2022083889 @default.
- W2005419775 cites W2030104046 @default.
- W2005419775 cites W2037896239 @default.
- W2005419775 cites W2087520788 @default.
- W2005419775 cites W2095050457 @default.
- W2005419775 cites W2110065044 @default.
- W2005419775 cites W2113213855 @default.
- W2005419775 cites W2118916537 @default.
- W2005419775 cites W2182809693 @default.
- W2005419775 cites W2396376992 @default.
- W2005419775 cites W2431240235 @default.
- W2005419775 doi "https://doi.org/10.1016/j.cdp.2006.06.007" @default.
- W2005419775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17935913" @default.
- W2005419775 hasPublicationYear "2007" @default.
- W2005419775 type Work @default.
- W2005419775 sameAs 2005419775 @default.
- W2005419775 citedByCount "4" @default.
- W2005419775 countsByYear W20054197752017 @default.
- W2005419775 crossrefType "journal-article" @default.
- W2005419775 hasAuthorship W2005419775A5016817677 @default.
- W2005419775 hasAuthorship W2005419775A5017185687 @default.
- W2005419775 hasAuthorship W2005419775A5022175772 @default.
- W2005419775 hasAuthorship W2005419775A5023115923 @default.
- W2005419775 hasAuthorship W2005419775A5025449315 @default.
- W2005419775 hasAuthorship W2005419775A5039890157 @default.
- W2005419775 hasAuthorship W2005419775A5068891623 @default.
- W2005419775 hasAuthorship W2005419775A5084478593 @default.
- W2005419775 hasConcept C107130276 @default.
- W2005419775 hasConcept C121608353 @default.
- W2005419775 hasConcept C126322002 @default.
- W2005419775 hasConcept C141071460 @default.
- W2005419775 hasConcept C142724271 @default.
- W2005419775 hasConcept C143998085 @default.
- W2005419775 hasConcept C18903297 @default.
- W2005419775 hasConcept C2777286243 @default.
- W2005419775 hasConcept C2779134260 @default.
- W2005419775 hasConcept C2779399171 @default.
- W2005419775 hasConcept C2780474809 @default.
- W2005419775 hasConcept C2780849966 @default.
- W2005419775 hasConcept C2910049883 @default.
- W2005419775 hasConcept C71924100 @default.
- W2005419775 hasConcept C86803240 @default.
- W2005419775 hasConceptScore W2005419775C107130276 @default.
- W2005419775 hasConceptScore W2005419775C121608353 @default.
- W2005419775 hasConceptScore W2005419775C126322002 @default.
- W2005419775 hasConceptScore W2005419775C141071460 @default.
- W2005419775 hasConceptScore W2005419775C142724271 @default.
- W2005419775 hasConceptScore W2005419775C143998085 @default.
- W2005419775 hasConceptScore W2005419775C18903297 @default.
- W2005419775 hasConceptScore W2005419775C2777286243 @default.
- W2005419775 hasConceptScore W2005419775C2779134260 @default.
- W2005419775 hasConceptScore W2005419775C2779399171 @default.
- W2005419775 hasConceptScore W2005419775C2780474809 @default.
- W2005419775 hasConceptScore W2005419775C2780849966 @default.
- W2005419775 hasConceptScore W2005419775C2910049883 @default.
- W2005419775 hasConceptScore W2005419775C71924100 @default.
- W2005419775 hasConceptScore W2005419775C86803240 @default.
- W2005419775 hasIssue "4" @default.
- W2005419775 hasLocation W20054197751 @default.
- W2005419775 hasLocation W20054197752 @default.
- W2005419775 hasOpenAccess W2005419775 @default.
- W2005419775 hasPrimaryLocation W20054197751 @default.
- W2005419775 hasRelatedWork W1976778146 @default.
- W2005419775 hasRelatedWork W2005419775 @default.
- W2005419775 hasRelatedWork W2022650174 @default.
- W2005419775 hasRelatedWork W2055015577 @default.
- W2005419775 hasRelatedWork W2187601106 @default.
- W2005419775 hasRelatedWork W2405982484 @default.
- W2005419775 hasRelatedWork W2442196642 @default.
- W2005419775 hasRelatedWork W2462710631 @default.
- W2005419775 hasRelatedWork W2795910839 @default.
- W2005419775 hasRelatedWork W51967042 @default.
- W2005419775 hasVolume "31" @default.
- W2005419775 isParatext "false" @default.
- W2005419775 isRetracted "false" @default.
- W2005419775 magId "2005419775" @default.
- W2005419775 workType "article" @default.