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- W2005431113 abstract "The purpose of this investigation was to explore the effects of electrical gradients on the permeability and structure of the load urinary bladder and to compare these results with those produced by osmotic gradients. From this we hoped to gain new insight into permeation pathways across epithelia. A marked increase in conductance begins within 20 ms, when voltage gradients of several hundred mV are applied in either direction across the bladder. This is accompanied by increased permeability of both mannitol and 1,7-heptanediol. Electron microscopy shows that these gradients also produce “blisters” within the tight junctions of the bladder epithelium. However, this structural change occurs only after the conductance change is complete. Osmotic gradients applied in either direction across the epithelium produce conductance and permeability changes virtually identical to those produced electrically. Blisters are formed in the tight junctions only when the mucosal solution is made hypertonic. We conclude: (a) Blister formation in tight junctions does not cause the conductance and permeability changes. (b) Both polar and non-polar permeation pathways are altered. (c) Both types of gradient probably act by basically the same mechanism." @default.
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- W2005431113 date "1974-01-01" @default.
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- W2005431113 title "Electrically and osmotically induced changes in permeability and structure of toad urinary bladder" @default.
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- W2005431113 doi "https://doi.org/10.1016/0005-2736(74)90381-2" @default.
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