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- W2005432945 abstract "Several pathways of transmembrane signaling in lymphocytes involve protein-tyrosine phosphorylation. With the exception of p56lck, a tyrosine kinase specific to T lymphoid cells that associates with the T cell transmembrane proteins CD4 and CD8, the kinases that function in these pathways are unknown. A murine lymphocyte complementary DNA that represents a new member of the src family has now been isolated and characterized. This complementary DNA, termed blk (for B lymphoid kinase), specifies a polypeptide of 55 kilodaltons that is related to, but distinct from, previously identified retroviral or cellular tyrosine kinases. The protein encoded by blk exhibits tyrosine kinase activity when expressed in bacterial cells. In the mouse and among cell lines, blk is specifically expressed in the B cell lineage. The tyrosine kinase encoded by blk may function in a signal transduction pathway that is restricted to B lymphoid cells." @default.
- W2005432945 created "2016-06-24" @default.
- W2005432945 creator A5000064890 @default.
- W2005432945 creator A5026873741 @default.
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- W2005432945 date "1990-01-19" @default.
- W2005432945 modified "2023-10-14" @default.
- W2005432945 title "Specific Expression of a Tyrosine Kinase Gene, <i>blk</i> , in B Lymphoid Cells" @default.
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- W2005432945 doi "https://doi.org/10.1126/science.2404338" @default.
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