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- W2005441096 abstract "The 3-deaza and 7-deaza derivatives of 5'-amino-5'-deoxy-5'-noraristeromycin ( 6 and 7 , respectively) have been prepared from the common starting material (+)-(1 R ,4 S )-4-hydroxycyclopent-2-en-1-yl acetate ( 8 ). Two Pd(0)-catalyzed allylic substitution reactions afforded the desired azide intermediates, 12 and 16 , which were transformed to target compounds by standard procedures. These compounds were evaluated against a large number of viruses and found to be inactive except for weak effect against hepatitis B virus: 6 , EC 50 4.7 μM (3TC EC 50 0.056 μM); 7 , EC 50 4.8 μM (3TC EC 50 0.063 μM)." @default.
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- W2005441096 date "2006-01-01" @default.
- W2005441096 modified "2023-09-26" @default.
- W2005441096 title "The 3-Deaza and 7-Deaza Derivatives of 5'-Amino-5'-deoxy-5'-noraristeromycin" @default.
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- W2005441096 doi "https://doi.org/10.1135/cccc20061122" @default.
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