Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005442679> ?p ?o ?g. }
- W2005442679 endingPage "347" @default.
- W2005442679 startingPage "339" @default.
- W2005442679 abstract "Background: Previous work has suggested that acute depletion of the serotonin (5-HT) precursor tryptophan (TRP) causes transient compensatory changes in the 5-HT system that might be exploited for their antidepressant effects. In this study, neuroendocrine and mood responses to intravenous (i.v.) infusion of TRP were examined in order to evaluate central 5-HT function in depressed patients undergoing acute TRP depletion. Methods: Thirty-eight drug-free patients with DSM-III-R major depression participated. Each patient underwent two randomized, double-blind TRP depletion tests, one sham and one active. At the estimated time of maximum TRP depletion, each patient received an i.v. infusion of TRP 100 mg/kg. Blood was obtained for serum cortisol, prolactin, and growth hormone. Mood was assessed using standardized rating scales. Results: The cortisol response to i.v. TRP was significantly greater during TRP depletion than during sham depletion. Depressive symptoms showed a tendency to decrease after i.v. TRP following active, but not sham, TRP depletion. Conclusions: These findings are consistent with the present hypothesis and previous evidence that acute TRP depletion in drug-free depressed patients induces compensatory upregulation of postsynaptic 5-HT receptors. These changes are insufficient to serve as a means of effecting clinical improvement, but suggest that the antidepressant properties of rapid, marked manipulations of 5-HT function warrant further study." @default.
- W2005442679 created "2016-06-24" @default.
- W2005442679 creator A5019555383 @default.
- W2005442679 creator A5029861832 @default.
- W2005442679 creator A5030853392 @default.
- W2005442679 creator A5031601763 @default.
- W2005442679 creator A5039312313 @default.
- W2005442679 date "1998-03-01" @default.
- W2005442679 modified "2023-09-26" @default.
- W2005442679 title "The Neurobiology of Tryptophan Depletion in Depression: Effects of Intravenous Tryptophan Infusion" @default.
- W2005442679 cites W143743334 @default.
- W2005442679 cites W187471295 @default.
- W2005442679 cites W1965353536 @default.
- W2005442679 cites W1968064550 @default.
- W2005442679 cites W1971334427 @default.
- W2005442679 cites W1974569394 @default.
- W2005442679 cites W1974668241 @default.
- W2005442679 cites W1976033033 @default.
- W2005442679 cites W1977633073 @default.
- W2005442679 cites W1978341871 @default.
- W2005442679 cites W1979332175 @default.
- W2005442679 cites W1984516066 @default.
- W2005442679 cites W1984932212 @default.
- W2005442679 cites W1988319822 @default.
- W2005442679 cites W1993015131 @default.
- W2005442679 cites W1993357824 @default.
- W2005442679 cites W1996880591 @default.
- W2005442679 cites W1997018309 @default.
- W2005442679 cites W1999846147 @default.
- W2005442679 cites W2000353120 @default.
- W2005442679 cites W2000685563 @default.
- W2005442679 cites W2004470488 @default.
- W2005442679 cites W2006464818 @default.
- W2005442679 cites W2007851776 @default.
- W2005442679 cites W2015827110 @default.
- W2005442679 cites W2024565627 @default.
- W2005442679 cites W2029172086 @default.
- W2005442679 cites W2029755823 @default.
- W2005442679 cites W2030936795 @default.
- W2005442679 cites W2032466533 @default.
- W2005442679 cites W2032766740 @default.
- W2005442679 cites W2033397874 @default.
- W2005442679 cites W2034460244 @default.
- W2005442679 cites W2041717424 @default.
- W2005442679 cites W2043567599 @default.
- W2005442679 cites W2044323467 @default.
- W2005442679 cites W2048671594 @default.
- W2005442679 cites W2050560210 @default.
- W2005442679 cites W2053143503 @default.
- W2005442679 cites W2054149718 @default.
- W2005442679 cites W2056898436 @default.
- W2005442679 cites W2062815987 @default.
- W2005442679 cites W2067495470 @default.
- W2005442679 cites W2068013902 @default.
- W2005442679 cites W2070431563 @default.
- W2005442679 cites W2071359470 @default.
- W2005442679 cites W2076309522 @default.
- W2005442679 cites W2076953813 @default.
- W2005442679 cites W2080036176 @default.
- W2005442679 cites W2089452749 @default.
- W2005442679 cites W2091310160 @default.
- W2005442679 cites W2093197870 @default.
- W2005442679 cites W2093830266 @default.
- W2005442679 cites W2093961716 @default.
- W2005442679 cites W2096933190 @default.
- W2005442679 cites W2107964407 @default.
- W2005442679 cites W2111243367 @default.
- W2005442679 cites W2114772172 @default.
- W2005442679 cites W2117122674 @default.
- W2005442679 cites W2127017530 @default.
- W2005442679 cites W2127923250 @default.
- W2005442679 cites W2147418766 @default.
- W2005442679 cites W2160070901 @default.
- W2005442679 cites W2319064429 @default.
- W2005442679 cites W2345595328 @default.
- W2005442679 doi "https://doi.org/10.1016/s0006-3223(97)00284-9" @default.
- W2005442679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9513749" @default.
- W2005442679 hasPublicationYear "1998" @default.
- W2005442679 type Work @default.
- W2005442679 sameAs 2005442679 @default.
- W2005442679 citedByCount "57" @default.
- W2005442679 countsByYear W20054426792012 @default.
- W2005442679 countsByYear W20054426792013 @default.
- W2005442679 countsByYear W20054426792014 @default.
- W2005442679 countsByYear W20054426792015 @default.
- W2005442679 countsByYear W20054426792016 @default.
- W2005442679 countsByYear W20054426792017 @default.
- W2005442679 countsByYear W20054426792019 @default.
- W2005442679 countsByYear W20054426792022 @default.
- W2005442679 crossrefType "journal-article" @default.
- W2005442679 hasAuthorship W2005442679A5019555383 @default.
- W2005442679 hasAuthorship W2005442679A5029861832 @default.
- W2005442679 hasAuthorship W2005442679A5030853392 @default.
- W2005442679 hasAuthorship W2005442679A5031601763 @default.
- W2005442679 hasAuthorship W2005442679A5039312313 @default.
- W2005442679 hasBestOaLocation W20054426791 @default.
- W2005442679 hasConcept C118552586 @default.
- W2005442679 hasConcept C126322002 @default.