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- W2005442875 abstract "Background: Homocysteine is a cardiovascular disease risk factor. We investigated, both in subjects with past plasma total homocysteine (tHcy) test indications and healthy adults, the diagnostic value of a fasting (tHcy) (f-tHcy) and the added value of a post-methionine-load tHcy (postload-tHcy). Methods: Plasma homocysteine cut-off values were retrospectively used for hyperhomocysteinemia assessment in 3477 subjects with past tHcy test indications and 177 apparently healthy subjects. Cut-off values were based on reference limits (f-tHcy≤15.0; postload-tHcy≤50.0 μmol/l), relative risk (f-tHcy≤12.0, postload-tHcy≤38.0; or f-tHcy≤10.0 μmol/l) and vitamin-optimized reference limits (f-tHcy≤9.3; postload-tHcy≤35.1 μmol/l). Results: Use of the American Heart Association 10 μmol/l f-tHcy cut-off value gave hyperhomocysteinemia prevalences of 65% in subjects with past tHcy test indications and 50% in healthy subjects. The combination of the vitamin-optimized reference limits for f-tHcy and postload-tHcy gave a hyperhomocysteinemia prevalence of 79% in subjects with tHcy test indications, of which only 5% was on account of increased postload-tHcy. Corresponding values for healthy subjects were 68% and 3%, respectively. Conclusions: Employment of a 10 μmol/l (American Heart Association) or 9.3 μmol/l (vitamin-optimized reference) cut-off value leaves no indications for tHcy testing from an evidence-based point-of-view." @default.
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- W2005442875 date "2003-05-01" @default.
- W2005442875 modified "2023-09-25" @default.
- W2005442875 title "Low diagnostic value of fasting and post-methionine load homocysteine tests. A study in Dutch subjects with homocysteine test indications" @default.
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- W2005442875 doi "https://doi.org/10.1016/s0009-8981(03)00078-0" @default.
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