Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005443172> ?p ?o ?g. }
- W2005443172 endingPage "1505" @default.
- W2005443172 startingPage "1497" @default.
- W2005443172 abstract "Abstract Neointima, defined as abnormal growth of the intimal layer of blood vessels, is believed to be a critical event in the development of vascular occlusive disease. Although resveratrol's inhibitory effects on proliferation and migration of vascular smooth muscle cells has been reported, its activity on neointimal formation is still unclear. Oral administration of trans ‐resveratrol significantly suppressed intimal hyperplasia in a wire‐injured femoral artery mouse model. In cultured vascular smooth muscle cells, trans ‐resveratrol inhibited platelet‐derived growth factor‐stimulated DNA synthesis and cell proliferation with down‐regulation of cyclin D and pRB. Moreover, platelet‐derived growth factor‐induced production of reactive oxygen species was inhibited by trans ‐resveratrol and the compound induced heme oxygenase‐1 (HO‐1). The anti‐proliferative activity of trans ‐resveratrol was reversed by an HO‐1 inhibitor, ZnPPIX. Subcellular fractionation and reporter gene analyses revealed that trans ‐resveratrol increased the level of nuclear Nrf2 and antioxidant response element reporter activity, and that these were essential for the induction of HO‐1. Trans ‐resveratrol also enhanced the activities of phosphatidyl inositol 3‐kinase and extracellular signal regulated kinase, and phosphatidyl inositol 3‐kinase was required for Nrf2/antioxidant response element‐dependent HO‐1 induction. These data have significant implications for the elucidation of the pharmacological mechanism by which trans ‐resveratrol prevents vascular occlusive diseases." @default.
- W2005443172 created "2016-06-24" @default.
- W2005443172 creator A5002218943 @default.
- W2005443172 creator A5026715008 @default.
- W2005443172 creator A5036364665 @default.
- W2005443172 creator A5049188837 @default.
- W2005443172 creator A5066851759 @default.
- W2005443172 creator A5067065425 @default.
- W2005443172 creator A5071757863 @default.
- W2005443172 date "2010-05-19" @default.
- W2005443172 modified "2023-10-18" @default.
- W2005443172 title "Inhibition of neointimal formation by trans-resveratrol: Role of phosphatidyl inositol 3-kinase-dependent Nrf2 activation in heme oxygenase-1 induction" @default.
- W2005443172 cites W1658843865 @default.
- W2005443172 cites W1978658307 @default.
- W2005443172 cites W1982130940 @default.
- W2005443172 cites W1982283172 @default.
- W2005443172 cites W1984665850 @default.
- W2005443172 cites W1991512665 @default.
- W2005443172 cites W1993735050 @default.
- W2005443172 cites W2000400362 @default.
- W2005443172 cites W2000495014 @default.
- W2005443172 cites W2020433921 @default.
- W2005443172 cites W2025260754 @default.
- W2005443172 cites W2026952784 @default.
- W2005443172 cites W2029868256 @default.
- W2005443172 cites W2039262601 @default.
- W2005443172 cites W2041274415 @default.
- W2005443172 cites W2045697440 @default.
- W2005443172 cites W2048569323 @default.
- W2005443172 cites W2065489192 @default.
- W2005443172 cites W2068658615 @default.
- W2005443172 cites W2069546816 @default.
- W2005443172 cites W2073679813 @default.
- W2005443172 cites W2079720923 @default.
- W2005443172 cites W2080221988 @default.
- W2005443172 cites W2085520872 @default.
- W2005443172 cites W2086140220 @default.
- W2005443172 cites W2090234441 @default.
- W2005443172 cites W2092479473 @default.
- W2005443172 cites W2099952906 @default.
- W2005443172 cites W2105212289 @default.
- W2005443172 cites W2110031947 @default.
- W2005443172 cites W2111496692 @default.
- W2005443172 cites W2112252897 @default.
- W2005443172 cites W2114100281 @default.
- W2005443172 cites W2120514800 @default.
- W2005443172 cites W2121794299 @default.
- W2005443172 cites W2123198444 @default.
- W2005443172 cites W2127860658 @default.
- W2005443172 cites W2148015625 @default.
- W2005443172 cites W2154587590 @default.
- W2005443172 cites W2155554171 @default.
- W2005443172 cites W2158793775 @default.
- W2005443172 cites W2161262137 @default.
- W2005443172 cites W2163016231 @default.
- W2005443172 cites W2186542461 @default.
- W2005443172 cites W2324489407 @default.
- W2005443172 cites W2413475876 @default.
- W2005443172 cites W4235996718 @default.
- W2005443172 doi "https://doi.org/10.1002/mnfr.201000016" @default.
- W2005443172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20486211" @default.
- W2005443172 hasPublicationYear "2010" @default.
- W2005443172 type Work @default.
- W2005443172 sameAs 2005443172 @default.
- W2005443172 citedByCount "43" @default.
- W2005443172 countsByYear W20054431722012 @default.
- W2005443172 countsByYear W20054431722013 @default.
- W2005443172 countsByYear W20054431722014 @default.
- W2005443172 countsByYear W20054431722016 @default.
- W2005443172 countsByYear W20054431722017 @default.
- W2005443172 countsByYear W20054431722019 @default.
- W2005443172 countsByYear W20054431722020 @default.
- W2005443172 countsByYear W20054431722021 @default.
- W2005443172 countsByYear W20054431722022 @default.
- W2005443172 countsByYear W20054431722023 @default.
- W2005443172 crossrefType "journal-article" @default.
- W2005443172 hasAuthorship W2005443172A5002218943 @default.
- W2005443172 hasAuthorship W2005443172A5026715008 @default.
- W2005443172 hasAuthorship W2005443172A5036364665 @default.
- W2005443172 hasAuthorship W2005443172A5049188837 @default.
- W2005443172 hasAuthorship W2005443172A5066851759 @default.
- W2005443172 hasAuthorship W2005443172A5067065425 @default.
- W2005443172 hasAuthorship W2005443172A5071757863 @default.
- W2005443172 hasConcept C126322002 @default.
- W2005443172 hasConcept C134018914 @default.
- W2005443172 hasConcept C181199279 @default.
- W2005443172 hasConcept C184235292 @default.
- W2005443172 hasConcept C185592680 @default.
- W2005443172 hasConcept C2776217839 @default.
- W2005443172 hasConcept C2776816829 @default.
- W2005443172 hasConcept C2778095995 @default.
- W2005443172 hasConcept C2778283817 @default.
- W2005443172 hasConcept C2778583881 @default.
- W2005443172 hasConcept C2779219270 @default.
- W2005443172 hasConcept C2779395532 @default.
- W2005443172 hasConcept C2992686903 @default.
- W2005443172 hasConcept C55493867 @default.
- W2005443172 hasConcept C71924100 @default.