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- W2005444787 abstract "A series of novel 1,2-dithiolan-4-yl benzoate compounds were synthesized and evaluated for in vitro PTP1B inhibitory activity. Some derivatives exhibited improved PTP1B inhibitory activity and selectivity compared to hit 6a, a compound from in-house library screening inspired by marine cyclic disulfide. The preliminary SAR analysis with assistance of molecular modeling approach revealed 6j (IC50=0.59μM) as the most potent PTP1B inhibitor among all derivatives." @default.
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- W2005444787 date "2015-05-01" @default.
- W2005444787 modified "2023-10-16" @default.
- W2005444787 title "Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors" @default.
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- W2005444787 doi "https://doi.org/10.1016/j.bmcl.2015.03.060" @default.
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