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• W2005445328 abstract "Alcoholism is rampant in modern society and some antioxidant compound could perhaps be useful to reduce the damage done by alcohol consumption and abstinence. The present study was undertaken to investigate the association of N-acetylcysteine (NAC) intake, alcoholism, and alcohol abstinence on lipid profile, in vivo low-density lipoprotein (LDL) oxidation, oxidative stress, and antioxidant status in serum and liver of rats. Initially, male Wistar 30 rats were divided into two groups: (C, N = 6) given standard chow and water; (E, N = 24) receiving standard chow and aqueous ethanol solution in semi-voluntary research. After 30 days of ethanol exposure, (E) group was divided into four subgroups (N = 6/group): (E-E) continued drinking 30% ethanol solution; (E-NAC) drinking ethanol solution containing 2 g/L NAC; (AB) changed ethanol solution to water; (AB-NAC) changed ethanol to aqueous solution 2 g/L NAC. After 15 days of the E-group division, E-E rats had higher serum alanine transaminase, lower body weight, and surface area, despite higher energy intake than C. E-E rats had also lower feed efficiency, dyslipidemia with enhanced triacylglycerol, very low-density lipoprotein (VLDL), lipid hydroperoxide (LH) and in vivo oxidized-LDL (ox-LDL). AB, E-NAC, and AB-NAC rats ameliorated serum oxidative stress markers and normalized serum lipids. E-E rats had higher hepatic LH and lower reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio than C, indicating hepatic oxidative stress. AB and E-NAC rats normalized hepatic LH, GSSG, and the GSH/GSSG ratio, compared to E-E. AB-NAC rats had the lowest serum ox-LDL, hepatic LH levels, and the highest GSH reductase activity in hepatic tissue. In conclusion, the present study brought new insights into alcohol consumption, because ethanol exposure enhanced serum in vivo ox-LDL, as well as serum and hepatic oxidative stress. N-acetylcysteine offers promising therapeutic value to inhibit ethanol-induced adverse effects. Ethanol withdrawal had beneficial effects on serum lipids, but was more effective when coupled with NAC supplementation. Ethanol abstinence and NAC intake interact synergistically, improving serum lipids and hepatic antioxidant defenses." @default.
• W2005445328 created "2016-06-24" @default.
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• W2005445328 date "2009-03-01" @default.
• W2005445328 modified "2023-10-01" @default.
• W2005445328 title "Effects of N-acetylcysteine on alcohol abstinence and alcohol-induced adverse effects in rats" @default.
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• W2005445328 cites W1775749144 @default.
• W2005445328 cites W1819789947 @default.
• W2005445328 cites W1839068802 @default.
• W2005445328 cites W1964806845 @default.
• W2005445328 cites W1967493579 @default.
• W2005445328 cites W1970400601 @default.
• W2005445328 cites W1972258793 @default.
• W2005445328 cites W1974794685 @default.
• W2005445328 cites W1977303456 @default.
• W2005445328 cites W1979209029 @default.
• W2005445328 cites W1980052326 @default.
• W2005445328 cites W1981470256 @default.
• W2005445328 cites W1991007222 @default.
• W2005445328 cites W1993721566 @default.
• W2005445328 cites W1995990906 @default.
• W2005445328 cites W2000066012 @default.
• W2005445328 cites W2005266392 @default.
• W2005445328 cites W2006339512 @default.
• W2005445328 cites W2007064404 @default.
• W2005445328 cites W2008106629 @default.
• W2005445328 cites W2009824332 @default.
• W2005445328 cites W2012508659 @default.
• W2005445328 cites W2014218268 @default.
• W2005445328 cites W2015306246 @default.
• W2005445328 cites W2019608003 @default.
• W2005445328 cites W2025122609 @default.
• W2005445328 cites W2032078431 @default.
• W2005445328 cites W2035536340 @default.
• W2005445328 cites W2037000525 @default.
• W2005445328 cites W2041029983 @default.
• W2005445328 cites W2041729389 @default.
• W2005445328 cites W2045877180 @default.
• W2005445328 cites W2048695662 @default.
• W2005445328 cites W2051473277 @default.
• W2005445328 cites W2053197080 @default.
• W2005445328 cites W2058054155 @default.
• W2005445328 cites W2060452153 @default.
• W2005445328 cites W2066062087 @default.
• W2005445328 cites W2068043284 @default.
• W2005445328 cites W2070998354 @default.
• W2005445328 cites W2072244763 @default.
• W2005445328 cites W2078843599 @default.
• W2005445328 cites W2086597762 @default.
• W2005445328 cites W2086686581 @default.
• W2005445328 cites W2094078687 @default.
• W2005445328 cites W2098979202 @default.
• W2005445328 cites W2104093946 @default.
• W2005445328 cites W2105385967 @default.
• W2005445328 cites W2108576543 @default.
• W2005445328 cites W2122201766 @default.
• W2005445328 cites W2124816752 @default.
• W2005445328 cites W2130441086 @default.
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• W2005445328 doi "https://doi.org/10.1016/j.alcohol.2008.12.003" @default.
• W2005445328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19251114" @default.
• W2005445328 hasPublicationYear "2009" @default.
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